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Open Science: a Shift in the Conversation
, 2019 Keynote talk at the Open Science Fair 2019, Porto, Portugal. Perhaps the most sincere and heart felt talk I have ever given about Open Science. I talk about things like research excellence, and how much damage has already done to science. I express the desire to shift the conversation towards topics like #failtales, mental health, reform of the ...
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Modelling displacements and velocities [PDF]
, 2010 In this unit you will see first how to convert vectors from geometric form, in terms of a magnitude and direction, to component form, and then how conversion in the opposite sense is accomplished. The ability to convert between these different forms of a
Open University
core
Conversion from laparoscopic to open cholecystectomy
British Journal of Surgery, 2006 The timing of surgery is ...
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A multicenter, primary-care-based, open-label study to assess the success of converting opioid-experienced patients with chronic moderate-to-severe pain to morphine sulfate and naltrexone hydrochloride extended-release capsules using a standardized conversion guide [PDF]
, 2015 Beatrice Setnik,1 Carl L Roland,1 Kenneth W Sommerville,1,2 Glenn C Pixton,1 Robert Berke,3,4 Anne Calkins,5 Veeraindar Goli1,2 1Pfizer Inc, 2Duke University Medical Center, Durham, NC, USA; 3Family Health Medical Services PLLC, Mayville, 4Department of ...
Sommerville KW +7 more
core
Open Science: A Candid Conversation
Journal of Advanced Academics, 2019 In response to concerns about the credibility of many published research findings, open science reforms such as preregistration, data sharing, and alternative forms of publication are being increasingly adopted across scientific communities. Although journals on giftedness and advanced academic research have already implemented several of these ...
Makel , Matthew, Smith , Kendal
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Operant procedures applied to a conversion disorder [PDF]
, 1995 Contains fulltext : 29789.pdf (Publisher’s version ) (Open Access)Conversion symptoms, as identified by the existing classification systems, do not form a single unitary class.
Hanno P. van der Heijden +7 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source