Results 121 to 130 of about 836,434 (299)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Intraoperative Gallbladder Scoring Predicts Difficulty of Surgery and Conversion of Laparoscopic to Open Cholecystectomy

Pakistan Armed Forces Medical Journal
Objective: To determine the ability of “Gallbladder Operating Score (G10)” to predict difficulty of surgery and timely conversion of laparoscopic to open cholecystectomy. Study Design: Cross sectional study.
Waleed Umer, Rifaat Qamar Naqvi, Fahad Shakil, Mansoor Tariq   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Factors affecting conversion of laparoscopic cholecystectomy to open surgery [PDF]

, 1996
Objective: To identify the risk factors predictive of conversion of laparoscopic cholecystectomy to open surgery. Design: Demographic, ultrasonographic, and operative data of patients who underwent laparoscopic cholecystectomy were analyzed.
Lo, CM, Lai, ECS, Fan, ST, Chu, KM, Liu, CL   +4 more
core  

Towards debate and open conversation [PDF]

Scandinavian Economic History Review, 2016
Ojala, J., Reckendrees, A.
openaire   +3 more sources

Discrepancies in survival after conversion to open in minimally invasive pancreatoduodenectomy. [PDF]

Am J Surg, 2023
Villano AM, Ruth K, Castellanos J, Farma JM, Reddy SS.   +4 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Keeping the conversation open

Theology in Scotland
The Second Vatican Council (1962–65) set out a new vision of the role of lay people in the Roman Catholic Church whereby they were no longer seen as passive recipients of clerical initiatives, but as active ministers of the Gospel. This article describes the historical context from which Vatican II emerged and outlines the scale and significance of the
openaire   +1 more source

Emergent Conversion to Open Heart Surgery during Transcatheter Aortic Valve Implantation: The Presence of a Rescue Team Improves Outcomes. [PDF]

J Clin Med, 2023
Nasso G, Vignaroli W, Contegiacomo G, Marchese A, Fattouch K, D'Alessandro P, Brigiani MS, Vitobello V, Triggiani V, Demola MA, Tonioni S, Paparella D, Sechi S, Bonifazi R, Santarpino G, Resta F, Bartolomucci F, Lorusso R, Larosa C, Valenti G, Tito A, Moscarelli M, Margari V, Fiore F, Condello I, Speziale G.   +25 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source