Results 171 to 180 of about 836,434 (299)

C-reactive protein as a predicting factor for difficult laparoscopic cholecystectomy or its conversion to open cholecystectomy in acute calculous cholecystitis: an observational study. [PDF]

BMC Surg
Rayamajhi BB, Shrivastav A, Karki G, Ayer DB, Pradhan SK.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Risk Factors Associated With Unplanned Conversion to Open in Radical and Partial Nephrectomy. [PDF]

Cureus
Fink BA, Son Y, Toumazos KC, DeMario VK, Flemming JP, Covelle N, Wesemann LB, Wu E, Patel VJ, Patel D, Mueller TJ.   +10 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Opening the Conversation

This editorial introduces the inaugural issue of AI & Antiquity: Journal of Teaching and Technology in Ancient Studies, situating the project within the broader debates on artificial intelligence and higher education. Far from conceiving AI as a threat, the journal embraces it as an opportunity to rethink the purposes and methods of teaching Ancient ...
openaire   +1 more source

Effect of unplanned conversion to open surgery on resection margins and complications in laparoscopic pancreaticoduodenectomy: a systematic review and meta-analysis with meta-regression. [PDF]

Ann R Coll Surg Engl
Hajibandeh S, Hajibandeh S, Alazab J, Alazab H, Safiru M, Satyadas T.   +5 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Effect of unplanned conversion to open surgery on resection margins and postoperative complications in minimally-invasive resection of colorectal liver metastases: A systematic review and meta-analysis with meta-regression. [PDF]

Ann Hepatobiliary Pancreat Surg
Hajibandeh S, Hajibandeh S, Tsaramanidis S, Mirza AS, Siriwardena AK, Jamdar S, de Liguori Carino N, Satyadas T.   +7 more
europepmc   +1 more source

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. [PDF]

Nat Commun, 2020
Zhang H, Pan Y, Hu L, Hudson MA, Hofstetter KS, Xu Z, Rong M, Wang Z, Prasad BVV, Lockless SW, Chiu W, Zhou M.   +11 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source