Results 241 to 250 of about 836,434 (299)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Vasa Vasorum-A Silent Enemy After EVAR: A Case Report and Review of the Literature. [PDF]

Clin Pract
Prentzas I, Leivaditis V, Andrikopoulou C, Nikolakopoulos K, Papageorgopoulou C, Tabaku K, Stathopoulou M, Papathanassiou Z, Tsantrizos P, Mulita F, Katsanos K, Papadoulas S.   +11 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Scaling Up Is Not the Same but Bigger: Overcoming (Some) Limitations in Enzymatic Decarboxylations in Rotating Bed Reactors in Deep Eutectic Solvents. [PDF]

Org Process Res Dev
Vaupel S, Meyer LE, Domínguez de María P, Kara S.   +3 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The breaking point in robotic pancreaticoduodenectomy: factors influencing conversion thresholds and early postoperative outcomes in a tertiary referral center. [PDF]

Surg Endosc
Fassari A, Wasielewski E, Castel A, Prudhomme H, Abdennebi S, Merdrignac A, Livin M, Robin F, Sulpice L.   +8 more
europepmc   +1 more source

Management of multiple common bile duct stones via laparoscopic transcholedochal exploration: an observational study. [PDF]

Front Surg
Dongol RM, Bogati AS, Neupane D, Awale L, Adhikary S, Pandit N.   +5 more
europepmc   +1 more source

RETRACTION: Novel C‐Terminal Heat Shock Protein 90 Inhibitors Target Breast Cancer Stem Cells and Block Migration, Self‐Renewal, and Epithelial–Mesenchymal Transition

Molecular Oncology, EarlyView.
wiley   +1 more source

Analysis of Hepatic Artery Reconstruction in Advanced Pancreatic Head Cancer. [PDF]

Plast Reconstr Surg Glob Open
Hamahata A, Ogura T, Fujinuma I, Futami H, Takahasi A.   +4 more
europepmc   +1 more source