Results 151 to 160 of about 197 (184)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

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Conversor CA-CC-CA Híbrido Para Aplicações em Sistemas de Conversão de Energia Eólica

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
Este artigo apresenta uma topologia de conversor CA-CC-CA hibrido para ser aplicado em sistemas de conversao de energia eolica. O conversor e composto de um conversor fonte de tensao do lado do gerador e um conversor fonte de corrente do lado da rede.
null Nayara Ingrid Lisboa Santos, null Louelson Afranio Leugirdes de Azevedo Cavalcanti Costa, null Maurício Beltrão de Rossiter Corrêa, null Montiê Alves Vitorino   +3 more
openaire   +2 more sources

CONVERSOR CA-CC MONOFÁSICO BIDIRECIONAL ISOLADO PARA APLICAÇÃO EM TRANSFORMADORES DE ESTADO SÓLIDO

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
Neste trabalho ´e apresentada uma topologia de conversor CA-CC monof´asico para aplica¸c˜ao em Transformador de Estado S´olido (TES), denominado ND1, que resulta da combina¸c˜ao de dois bra¸cos NPC (Neutral Point Clamped) de trˆes n´iveis e que apresenta caracter´isticas de um conversor DAB (Dual Active Bridge).
null José Janiere Silva de Souza, null Luan Carlos dos Santos Mazza, null Fernando Luiz Marcelo Antunes, null Demercil de Souza Oliveira Júnior, null Cicero Alisson dos Santos, null Raimundo Nonato Moura de Oliveira, null Juliano de Oliveira Pacheco   +6 more
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REAPROVEITAMENTO DE COMPONENTES ELETRÔNICOS PARA O DESENVOLVIMENTO DE UMA BANCADA DIDÁTICA APLICADA AO ENSINO-APRENDIZAGEM DOS CONVERSORES CA-CC

Proceedings of the 51 Brasilian Congress of Engineering Education, 2023

Nathália de Castro Nascimento, Lucas Lobato Chagas, Silzamar de Moraes Santos, Moisés Hamssés Sales de Sousa, Lucas do Nascimento Raiol   +4 more
openaire   +1 more source

Algoritmo de Fluxo de Potência para Redes de Distribuição Híbridas CA-CC Considerando os Modos de Controle dos Conversores

Proceedings do Simpósio Brasileiro de Sistemas Elétricos, 2023
null Elson N. M. Silva, null Anselmo B. Rodrigues, null Maria G. Silva   +2 more
openaire   +1 more source

Uma contribuição ao estudo de VTCDs aplicado a equipamentos eletronicos alimentados por conversor CA-CC

2021
openaire   +1 more source

Conversor CA-CC Boost com PFC Ativo 2 kW

Proceedings of the 17th Seminar on Power Electronics and Control (SEPOC 2025)
RAFAELO DAMIANI, JúLIO RADAVELLI, VAGNER MACIEL CUNHA, MURILO FRAGA ROCHA   +3 more
openaire   +1 more source