Results 151 to 160 of about 16,341 (187)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

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Conversor CA-CC-CA Híbrido Para Aplicações em Sistemas de Conversão de Energia Eólica

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
Este artigo apresenta uma topologia de conversor CA-CC-CA hibrido para ser aplicado em sistemas de conversao de energia eolica. O conversor e composto de um conversor fonte de tensao do lado do gerador e um conversor fonte de corrente do lado da rede.
null Nayara Ingrid Lisboa Santos, null Louelson Afranio Leugirdes de Azevedo Cavalcanti Costa, null Maurício Beltrão de Rossiter Corrêa, null Montiê Alves Vitorino   +3 more
semanticscholar   +4 more sources

CONVERSOR CA-CC MONOFÁSICO BIDIRECIONAL ISOLADO PARA APLICAÇÃO EM TRANSFORMADORES DE ESTADO SÓLIDO

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
Neste trabalho ´e apresentada uma topologia de conversor CA-CC monof´asico para aplica¸c˜ao em Transformador de Estado S´olido (TES), denominado ND1, que resulta da combina¸c˜ao de dois bra¸cos NPC (Neutral Point Clamped) de trˆes n´iveis e que apresenta caracter´isticas de um conversor DAB (Dual Active Bridge).
null José Janiere Silva de Souza, null Luan Carlos dos Santos Mazza, null Fernando Luiz Marcelo Antunes, null Demercil de Souza Oliveira Júnior, null Cicero Alisson dos Santos, null Raimundo Nonato Moura de Oliveira, null Juliano de Oliveira Pacheco   +6 more
openaire   +2 more sources

Conversor CA-CC Boost com PFC Ativo 2 kW

Proceedings of the 17th Seminar on Power Electronics and Control (SEPOC 2025)
RAFAELO DAMIANI, JúLIO RADAVELLI, VAGNER MACIEL CUNHA, MURILO FRAGA ROCHA   +3 more
openaire   +2 more sources

CONVERSOR CA-CC MONOFÁSICO MULTINÍVEL TIPO T MODIFICADO COM PFC E TENSÕES DE SAÍDA SIMÉTRICA BASEADAS NA CCME

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
null Fabíola Maria Alexandre Linard, null René Torrico Bascopé, null Francisco Everton Uchôa Reis, null Gabryel Figueiredo   +3 more
openaire   +2 more sources