Results 201 to 210 of about 1,928,423 (229)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Conversor CA-CC-CA Híbrido Para Aplicações em Sistemas de Conversão de Energia Eólica

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
Este artigo apresenta uma topologia de conversor CA-CC-CA hibrido para ser aplicado em sistemas de conversao de energia eolica. O conversor e composto de um conversor fonte de tensao do lado do gerador e um conversor fonte de corrente do lado da rede.
null Nayara Ingrid Lisboa Santos, null Louelson Afranio Leugirdes de Azevedo Cavalcanti Costa, null Maurício Beltrão de Rossiter Corrêa, null Montiê Alves Vitorino   +3 more
openaire   +2 more sources

CONVERSOR CA-CC MONOFÁSICO BIDIRECIONAL ISOLADO PARA APLICAÇÃO EM TRANSFORMADORES DE ESTADO SÓLIDO

Procedings do XXII Congresso Brasileiro de Autom�tica, 2018
Neste trabalho ´e apresentada uma topologia de conversor CA-CC monof´asico para aplica¸c˜ao em Transformador de Estado S´olido (TES), denominado ND1, que resulta da combina¸c˜ao de dois bra¸cos NPC (Neutral Point Clamped) de trˆes n´iveis e que apresenta caracter´isticas de um conversor DAB (Dual Active Bridge).
null José Janiere Silva de Souza, null Luan Carlos dos Santos Mazza, null Fernando Luiz Marcelo Antunes, null Demercil de Souza Oliveira Júnior, null Cicero Alisson dos Santos, null Raimundo Nonato Moura de Oliveira, null Juliano de Oliveira Pacheco   +6 more
openaire   +1 more source

REAPROVEITAMENTO DE COMPONENTES ELETRÔNICOS PARA O DESENVOLVIMENTO DE UMA BANCADA DIDÁTICA APLICADA AO ENSINO-APRENDIZAGEM DOS CONVERSORES CA-CC

Proceedings of the 51 Brasilian Congress of Engineering Education, 2023

Nathália de Castro Nascimento, Lucas Lobato Chagas, Silzamar de Moraes Santos, Moisés Hamssés Sales de Sousa, Lucas do Nascimento Raiol   +4 more
openaire   +1 more source