Results 61 to 70 of about 196 (183)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Estratégia de Conexão à Rede Elétrica do Gerador a Relutância Variável para Injeção de Potência Ativa

Eletrônica de Potência, 2014
Este artigo relata resultados de uma pesquisa no contexto das possibilidades de geração distribuída. Uma estratégia para injetar potência ativa na rede de alimentação é discutida e testada.
G. P. Viajante, D. A. Andrade, L. C. Gomes, J. A. Santos Jr, V. R. Bernardeli, A. W. F. V. Silveira, M. A. A. Freitas, F. S. Silva   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Low HDL-c levels at admission are associated with greater severity and worse clinical outcomes in patients with COVID-19 disease. [PDF]

Atheroscler Plus, 2023
Parra S, Saballs M, DiNubile M, Feliu M, Iftimie S, Revuelta L, Pavón R, Àvila A, Levinson S, Castro A.   +9 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Compensação De Desequilíbrios De Carga Empregando Conversor Estático Operando Com Modulação Em Largura De Pulso

Eletrônica de Potência, 2004
É cada vez maior a preocupação com a qualidade da energia elétrica tanto do ponto de vista do consumidor quanto da concessionária. Um dos grandes problemas encontrados é o desequilíbrio de correntes trifásicas devido à utilização de cargas monofásicas ...
Rodrigo Cutri, Lourenço Matakas Jr.
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Cardiovascular Statistics - Brazil 2021. [PDF]

Arq Bras Cardiol, 2022
Oliveira GMM, Brant LCC, Polanczyk CA, Malta DC, Biolo A, Nascimento BR, Souza MFM, Lorenzo AR, Fagundes Júnior AAP, Schaan BD, Castilho FM, Cesena FHY, Soares GP, Xavier Junior GF, Barreto Filho JAS, Passaglia LG, Pinto Filho MM, Machline-Carrion MJ, Bittencourt MS, Pontes Neto OM, Villela PB, Teixeira RA, Sampaio RO, Sampaio RO, Gaziano TA, Perel P, Roth GA, Ribeiro ALP.   +27 more
europepmc   +1 more source

Sistema de Controle Multi-Malhas para Inversor Multiníveis Quasi-Z-Source com uma Única Fonte de Entrada

Eletrônica de Potência, 2019
Uma estratégia de controle baseada na estrutura de malhas em cascata e controladores Proporcional-Integral (PI) e Proporcional-Ressonante (PR) é proposta e apresentada para o inversor Quasi-Z-Source em Cascata com uma Única Entrada (SS qZS-CMI).
Ronaldo A. Guisso, Tadeu Vargas, Mário L. S. Martins, Hélio L. Hey   +3 more
doaj   +1 more source