Results 161 to 170 of about 621,582 (323)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Characterizing the spatial structures of competing football teams. [PDF]

Sci Rep
Amichay G, Silva H, Brito J, Marcelino R.   +3 more
europepmc   +1 more source

RECURRENT DIMENSIONS AND DIOPHANTINE CONDITIONS OF DISCRETE DYNAMICAL SYSTEMS GIVEN BY CIRCLE MAPPINGS (Nonlinear Analysis and Convex Analysis)

, 2005
Koichiro Naito
openalex   +1 more source

Convex analysis in groups and semigroups: a sampler [PDF]

, 2015
Jonathan M. Borwein, Ohad Giladi
openalex   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Computational Analysis of the Energetic Stability of High-Entropy Structures of a Prototypical Lanthanide-Based Metal-Organic Framework. [PDF]

J Phys Chem C Nanomater Interfaces
Kumar SKA, Sava Gallis DF, Sholl DS.
europepmc   +1 more source

Simplifying Consensus Stability Analysis of Multi-Agent Systems Using the Concept of Convex Directions for Quasipolynomials

, 2021
Marco A. Gomez, Adrián Ramírez
openalex   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Multi-UAV forest area inspection path planning based on concave polygon region decomposition. [PDF]

Sci Rep
Kang B, Wang C, Su Y, Zeng J.
europepmc   +1 more source

Analysis of laminar flow of magnetorheological fluids in circular pipes based on non-convex constitutive model

, 2012
Cheng Zhang
openalex   +1 more source