Results 231 to 240 of about 11,287,559 (375)
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Chebyshev centers and radii for sets induced by quadratic matrix inequalities. [PDF]
Math Control Signal SystShakouri A, van Waarde HJ, Camlibel MK.
europepmc +1 more source
Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration
Advanced Science, EarlyView.Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin +7 more
wiley +1 more source
Optimization of Device-Free Localization with Springback Dual Models: A Synthetic and Analytical Framework. [PDF]
Sensors (Basel)Li J, Tan B, Qin Y, Mo Y.
europepmc +1 more source
On an Inequality for Convex Functions [PDF]
Proceedings of the American Mathematical Society, 1956 openaire +2 more sources
Functions with convex means [PDF]
Pacific Journal of Mathematics, 1964 Boehme, T. K., Bruckner, A. M.
openaire +2 more sources
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, EarlyView.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Ultrasound-based assessment of spinal muscle thickness and elasticity in patients with idiopathic scoliosis. [PDF]
Ultrasound JLei H, Meng L, Sun Y, Gou Y.
europepmc +1 more source