Results 41 to 50 of about 198,293 (212)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Computer-aided detection of colonic polyps with level set-based adaptive convolution in volumetric mucosa to advance CT colonography toward a screening modality

Cancer Management and Research, 2009
Hongbin Zhu1, Chaijie Duan1, Perry Pickhardt2, Su Wang1, Zhengrong Liang1,31Department of Radiology, 3Department of Computer Science, State University of New York, Stony Brook, NY, USA; 2Department of Radiology, University of Wisconsin Medical School ...
Hongbin Zhu, Chaijie Duan, Perry Pickhardt, Su Wang, et al.   +4 more
doaj  

SGLFormer: Spiking Global-Local-Fusion Transformer with high performance

Frontiers in Neuroscience
IntroductionSpiking Neural Networks (SNNs), inspired by brain science, offer low energy consumption and high biological plausibility with their event-driven nature.
Han Zhang, Han Zhang, Chenlin Zhou, Liutao Yu, Liwei Huang, Liwei Huang, Zhengyu Ma, Xiaopeng Fan, Xiaopeng Fan, Huihui Zhou, Yonghong Tian, Yonghong Tian   +11 more
doaj   +1 more source

Parallel Multi Channel Convolution using General Matrix Multiplication

, 2017
Convolutional neural networks (CNNs) have emerged as one of the most successful machine learning technologies for image and video processing. The most computationally intensive parts of CNNs are the convolutional layers, which convolve multi-channel ...
Anderson, Andrew, Gregg, David, Vasudevan, Aravind   +2 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

LVGG-IE: A Novel Lightweight VGG-Based Image Encryption Scheme

Entropy
Image security faces increasing challenges with the widespread application of computer science and artificial intelligence. Although chaotic systems are employed to encrypt images and prevent unauthorized access or tampering, the degradation that occurs ...
Mingliang Sun, Jie Yuan, Xiaoyong Li, Dongxiao Liu, Xinghai Wei   +4 more
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Brain tumor diagnosis techniques key achievements, lessons learned, and a new CNN architecture

The Egyptian Journal of Radiology and Nuclear Medicine
Background A brain tumor is an abnormal tissue growth in the skull that can damage healthy brain areas by exerting pressure. While early detection is vital for prevention, accurate diagnosis with computer-aided design (CAD) systems remains challenging ...
Gerges M. Salama, Mahmoud Khaled Abd-Ellah, Aziza I. Hussein, Esraa Salah Bayoumi, Shady Ashraf, Mohammed Safy   +5 more
doaj   +1 more source