Results 41 to 50 of about 4,252,298 (276)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

GAD:topology-aware time series anomaly detection

Tongxin xuebao, 2020
To solve the problems of anomaly detection,intelligent operation,root cause analysis of node equipment in the network,a graph-based gated convolutional codec anomaly detection model was proposed for time series data such as link delay,network throughput ...
Qi QI, Runye SHEN, Jingyu WANG
doaj   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Graph Neural Network for Traffic Flow Situation Prediction

Jisuanji kexue yu tansuo, 2021
Road network structure integrated traffic flow situation prediction is a highly nonlinear and complexly spatial-temporal dynamic correlation time-series data prediction problem. However, traditional traffic flow situation forecasting methods cannot model
JIANG Shan, DING Zhiming, XU Xinrun, YAN Jin
doaj   +1 more source

Time Series Encodings with Temporal Convolutional Networks

, 2020
The training of anomaly detection models usually requires labeled data. We present in this paper a novel approach for anomaly detection in time series which trains unsupervised using a convolutional approach coupled to an autoencoder framework. After training, only a small amount of labeled data is needed to adjust the anomaly threshold.
Markus Thill, Wolfgang Konen, Thomas Bäck   +2 more
openaire   +3 more sources

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Differentiation of the Mittag-Leffler Functions with Respect to Parameters in the Laplace Transform Approach

Mathematics, 2020
In this work, properties of one- or two-parameter Mittag-Leffler functions are derived using the Laplace transform approach. It is demonstrated that manipulations with the pair direct–inverse transform makes it far more easy than previous methods to ...
Alexander Apelblat
doaj   +1 more source

On Approximation of Convolutions by Accompanying Laws in the Scheme of Series [PDF]

Journal of Mathematical Sciences, 2014
The problem of the approximation of convolutions by accompanying laws in the scheme of series satisfying the infinitesimality condition is considered. It is shown that the quality of approximation depends essentially on the choice of centering constants.
openaire   +2 more sources