Results 161 to 170 of about 88,078 (309)

Implementation of the In Vitro Seizure Liability Assay (iLA^seizure) in Drug Discovery and Development: Mechanism of Action Case Studies. [PDF]

Pharmacol Res Perspect
Rockley K, Roberts R, Jennings H, Jones K, Maizières MA, Morton M.   +5 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Machine learning models for predicting postpartum convulsions using clinical indicators from PMA Ethiopia data. [PDF]

Sci Rep
Mulugeta C, Emagneneh T, Yetwale A, Yimer NB, Ayele M, Negese K, Tadese S, Alamrew A.   +7 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Distinct Roles of NMDA and AMPA Receptors in the Pathogenesis of Hyperbaric Oxygen-Induced Seizures. [PDF]

Biomedicines
Alekseeva O, Zaripov K, Vasilev D, Demchenko I.   +3 more
europepmc   +1 more source

Hypercalciuria in children with febrile convulsions

, 2001
Background: The purpose of the present study was to investigate whether idiopathic hypercalciuria may be implicated in the pathogenesis of febrile convulsions.
Papadimitriou, A, Garoufi, A, Nicolaidou, P, Georgouli, H   +3 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Real-World Safety of Concurrent Measles-Mumps-Rubella and Varicella Vaccination in Korean Infants: A Multicenter Self-Controlled Case Series Study. [PDF]

Vaccines (Basel)
Choi S, Ahn B, Lee Y, Kim G, Choe YJ, Choi YY.   +5 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Positive allosteric modulation of the delta opioid receptor attenuates depression-like and pain-like behaviors but does not promote convulsions. [PDF]

J Pharmacol Exp Ther
Jutkiewicz EM, Palleiko BA, Dripps IJ, Livingston KE, Roques BP, Clements BM, Traynor JR.   +6 more
europepmc   +1 more source