Results 51 to 60 of about 794,004 (244)

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Contrasting foraging strategies of seasonally segregated populations of the band-rumped storm-petrel at St Helena, South Atlantic

Movement Ecology
Background Allochrony can be a cause or consequence of speciation, either creating temporal reproductive isolation that reduces gene flow between diverging populations or reinforcing divergence that has already occurred through geographic isolation.
Annalea Beard, Frank Hailer, Steffen Oppel, Renata Medeiros, Leeann Henry, Alison Small, Richard A. Phillips, Robert J. Thomas   +7 more
doaj   +1 more source

Synergistic Effects in Multistate Black Electro‐Thermochromic Smart Windows for Energy‐Efficient Modulation of Solar Heating

Advanced Science, EarlyView.
Hybrid electro‐thermochromic smart windows are developed for dynamic climate control by integrating a redox‐matched black electrochromic gel with a paraffin‐based thermochromic film. This synergistic combination enables multimodal solar modulation, where photothermal heating from the electrochromic layer triggers thermochromic activation at lower ...
Xilu Wu, Lorenzo Vallan, Hao Li, Jaume Ramon Otaegui, Silvia Mena, Weizhong Jiang, Hongzhi Wang, Jonathan C. Barnes, Daniel Ruiz‐Molina, Kerui Li, Jordi Hernando, Claudio Roscini, Gonzalo Guirado   +12 more
wiley   +1 more source

Persistence of the invasive bird-parasitic fly Philornis downsi over the host interbreeding period in the Galapagos Islands

Scientific Reports, 2022
Many parasites of seasonally available hosts must persist through times of the year when hosts are unavailable. In tropical environments, host availability is often linked to rainfall, and adaptations of parasites to dry periods remain understudied.
Mariana Bulgarella, M. Piedad Lincango, Paola F. Lahuatte, Jonathan D. Oliver, Andrea Cahuana, Ismael E. Ramírez, Roxanne Sage, Alyssa J. Colwitz, Deborah A. Freund, James R. Miksanek, Roger D. Moon, Charlotte E. Causton, George E. Heimpel   +12 more
doaj   +1 more source

Spontaneous Cyclic Levitation of Glycerol‐Water Droplets at Low Pressures

Advanced Science, EarlyView.
Under low pressure, a minute glycerol addition transforms the chaotic dynamics of freezing water droplets into cyclic levitation. Freeze‐concentration preserves liquid pathways that relax expansion‐induced stress, while freezing point depression weakens asymmetric vaporization recoil.
Chen Xu, Renjie Hua, Wei Ma, Fuqiang Chu, Dong Liang, Xueshi Li, Qirui Zhang, Yuan Dong, Xuehu Ma, Xiao Yan, Shuhuai Yao   +10 more
wiley   +1 more source

Bee Habitat, but Not Bee Community Structure, Varies Across Grassland Management in Four National Parks in the Mid‐Atlantic, USA

Ecology and Evolution
National Park Service units in the United States play a large role in providing habitat for native pollinators. In parks that are established to preserve cultural landscapes, park managers recognize an opportunity to improve pollinator habitat while ...
Diane L. Larson, Michael Simanonok, Andrew Landsman, Jennifer L. Larson, Cora Davies, Clint R. V. Otto   +5 more
doaj   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

Thermal performance analysis for roofs with heat mitigation strategies in subtropical hot and humid regions

Scientific Reports
The thermal behavior of roofs significantly impacts the indoor thermal environment. Rooftop mitigation strategies (RMS), as effective measures to reduce cooling load and improve indoor thermal comfort, have been extensively studied.
Yueer He, Ziyin Yang, Yue Fan
doaj   +1 more source

Multi‐Functional Smart Skin for High‐Efficiency Energy‐Saving Buildings

Advanced Science, EarlyView.
A scalable multifunctional smart skin (MSS) with broadband modulation, zero‐energy input controllable operation mode, and thermal insulation is designed by assembling thermal managing unit of high solar reflectance and low thermal conductivity and actuation unit of multi‐responsive shape‐memory effect.
Zongxu Na, Li Yu, Bo Lu, Jing Li, Xianyang Yue, Qian Wang   +5 more
wiley   +1 more source