Results 41 to 50 of about 52,456 (207)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Experimental Study on Dynamic Characteristics of SCO2 Cycle Cold-end Printed Circuit Heat Exchanger

Yuanzineng kexue jishu, 2023
In the SCO2 Brayton cycle, the cold-end SCO2 working fluid is in a near-critical state, and the physical properties change drastically, which directly affects the efficiency of the whole cycle and the safety of system operation, so it is of great ...
HOU Min;LIU Xiuting;WANG Ye;WANG Wei;ZHUO Wenbin;ZHAO Quanbin
doaj  

Determining the Reliability of Clincher Coolers

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2018
For any industrial entity that is put into operation, the problem of maintaining its functioning if possible, with corresponding technical and technological parameters without failure is an important issue.
Teodor VASIU, Adina BUDIUL BERGHIAN
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

mirnylab/cooler: v0.7.10

, 2018
<p>Cooler is a Python support library for .cool files: an efficient storage format for high resolution genomic interaction matrices.</p> <p>The cooler package aims to provide the following functionality:</p> <ul> <li ...
Leonid Mirny (5684762), Nezar Abdennur, Nezar Abdennur (4238965), Anton Goloborodko (8145111), Maxim Imakaev, Anton Goloborodko, Maxim Imakaev (648765), Leonid Mirny   +7 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

mirnylab/cooler: v0.8.5

, 2019
<p>Cooler is a Python support library for .cool files: an efficient storage format for high resolution genomic interaction matrices.</p> <p>The cooler package aims to provide the following functionality:</p> <ul> <li ...
Kerpedjiev, Peter (5582225), Abdennur, Nezar (7116998), Fudenberg, Geoffrey, Strobelt, Hendrik, Strobelt, Hendrik (7117016), Abdennur, Nezar, Gehlenborg, Nils, Goloborodko, Anton (7117001), Gehlenborg, Nils (7117019), Mirny, Leonid (7117022), Imakaev, Maxim (7117004), Imakaev, Maxim, Kerpedjiev, Peter, Lee, Soo (7117013), Oullette, Scott, Lee, Soo, Goloborodko, Anton, Fudenberg, Geoffrey (7117007), Mirny, Leonid, Oullette, Scott (7117010)   +19 more
core   +1 more source

The Effect of a New Approach to Cooling the External Heat Exchange Surfaces of a Car Cooler with Air Nozzles on the Cooling Process

Applied Sciences
The paper deals with an experimental investigation of a new approach for cooling the external heat exchange surfaces of a cooler using an air pressure nozzle system.
Marek Lipnický, Zuzana Brodnianská
doaj   +1 more source

Thermal Performance of Cryogenic Micro-Pin Fin Coolers with Two-Phase Liquid Nitrogen Flows

Applied Sciences, 2021
This study experimentally explores the thermofluidic performance of a cryogenic micro-pin fin cooler with two-phase liquid nitrogen flows. The liquid nitrogen cooling system is introduced to investigate the performance of the micro-pin cooler in a ...
Kyoung Joon Kim, Hyeon Ho Yang, Wooheon Noh, Bongtae Han, Avram Bar-Cohen   +4 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source