Results 51 to 60 of about 12,663,341 (243)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen +6 morewiley +1 more sourceMethods of therapeutic hypothermia [PDF]
ABC: časopis urgentne medicine, 2015 INTODUCTION: Therapeutic hypothermia is a controlled lowering of the central body temperature to 32-34 *C for therapeutic purposes and is recommended as a standard in treating diseased patients.Radovanović Tanja, Vidović Mirko, Rakonjac Zagorka +2 moredoaj Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich +4 morewiley +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceThe MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment [PDF]
, 2012 The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied A. Wilson, Colling D, Tsenov R, M. Hills, R. Apsimon, Gamet, R., Kyberd, P., T. L. Hart, Grichine, V., S. Ramberger, R. Nicholson, W. Spensley, D. Cline, Wisting, H, Fletcher R, Hanke, K, V. Palladino, M. Khaleeq, Onel, Y, P. Smith, Kaplan DM, Colling, D., M. Littlefield, Kolev, D, Yang, X., Baynham, DE, Kim, Y. K., White C, Kasey V, E. McKigney, T. Savidge, Seviour, R, Sato A, Rimmer, R A, C. Heidt, White, C, Back, J, D. A. Sanders, Beuselinck, R, J. Alexander, Nichols, A., de Bari A, R. Fletcher, Ferri, F., Garoby, R., Onel, Y., Lee, K, Owens, P., D. Forrest, Neuffer D, Iaciofano, A, Mori, Y., Yoshimura, K, Onel Y, Cremaldi, L M, A. Jamdagni, R. Edgecock, Walaron, K., Verguilov V, Boyd S, Y. Karadzhov, Nelson C, Zisman, M S, Adey, D., Kirk, H, Zisman, M. S., Palladino, V., Rimmer, R.A., Tonazzo A, Cline, D., Masciocchi F, Mori Y, M. Vretenar, Savidge, T, Kolev, D., Tunnell, C D, Bogomilov, M, Forrest D, Apollonio, M., Cummings, MAC, Lombardi, A., Carlisle, T., Palladino, V, Lau, W, Tilley, K., Virostek, S., D. Adams, Yang, S., Dornan, P., Pastore F, Ramberger S, R. B. Palmer, Zheng SX, Wilson, A, Cooke, P, Kolev D, Lucchini G, Sandstrom, R, Gamet, R, Cobb, JH, Zheng, S.X., Edgecock R, Hanson, G.G., Charnley, G., A. Moss, Cooke P, DeMello A, Hart, TL, Witte H, Harrison, P, Verguilov, V, McKigney, E., Bonesini, M, Manfredini, A, Gregoire, G, Howlett L, Cirillo A, Rochford, J H, de Bari, A, ORESTANO, DOMIZIA, Long, K, Torun Y, Snopok, P., Cline, D, R. Beuselinck, Forrest, D, J. Leaver, Cummings, M A C, Nichols, A, Xu, F Y, Cummings, M. A. C., Xu, FY, Popovic, M., Back J, Hayler, T, Cooke, P., Y. Fukui, Collaboration, MICE, Kafka, G., M. Courthold, Nelson, C., K. Yoshimura, Bene P, Gilardoni S, Barber, G, R. Mazza, Parisi M., Summers DJ, Bogomilov, M., C. Nelson, Ramberger, S., Vretenar M, Adams, D., Savidge, T., Seviour, Rebecca, Hanson, GG, Hodgson P, A. Tonazzo, Cecchet, G., Ellis, M, Cremaldi, L.M., S. Blot, Janot, P, Fukui Y, M. Rayner, D. Huang, Strati, F., Courthold, M, Freemire, B., S. York, A. Lintern, F. Cadoux, Petitjean, C, Filthaut, F, Jamdagni A, R. Gamet, H. Haseroth, Yano T, Ishimoto, S., Y. Mori, Y. Ivaniouchenkov, Rimmer RA, Xu FY, Boyd, S, Graulich JS, Gamet R, Harrison P, Virostek, S, A. Dobbs, Cummings MAC, Hills, M, Carlisle, T, G. Kafka, Parisi, M, Nebrensky, J.J., Nebrensky JJ, Kuno, Y, Graulich, J.S., Graulich J-, Pasternak J, Kaplan, D. M., Lau W, Dobbs A, P. Dornan, P. Harrison, Hart, T. L., Oates, A., Cremaldi, L. M., Lombardi A, Xu, F.Y., Kim, YK, T. Hayler, F. J. P. Soler, L. Howlett, Haseroth, H., J. Gallardo, Yano, T, Martlew B, Barclay, P, Kaplan, D M, R. Garoby, P. Bene, G. Cecchet, C. D. Tunnell, U. Bravar, Nebrensky, J J, Orestano, D, Apollonio M, M. A. C. Cummings, Courthold, M., B. Freemire, Haseroth H, P. Barclay, Filthaut, F., Tortora, L, Greenwood, S., Soler, F.J.P., F. Y. Xu, Hayler, T., Palmer, RB, M. Parisi, V. Verguilov, Rayner, M., Tunnel, C.D., V. Kasey, Jones A, Kyberd, P, Wang, L, Fayer, S, Mazza, R, Littlefield, M., Hanson, G G, Mazza R, Blackmore V, K. Walaron, Vankova-Kirilova, G., Ivaniouchenkov, Y, Ivaniouchenkov Y, Griffiths, S., Ramberger, S, York, S., Gilardoni, S, Russinov, I, Heidt C, Nicholson, R., Bari Ad, Rochford, J. H., Tunnell CD, Filthaut F, Strati, F, Suzuki, S., Geer, S, S. Griffiths, Li D, Witte, H, Drumm, P, V. Grichine, Bogomilov M, T. Carlisle, D. Li, Li, D, Hodgson, P., E. Gschwendtner, Pastore, F, Zisman, M.S., Howlett, L, Kafka, G, Rayner, M, A. Alekou, Kim, Y K, Graulich, J -S, Wilson, A., Iaciofano A, Forrest, D., Fish, A., Moss A, Rimmer, RA, L. M. Cremaldi, V. Blackmore, Grichine V, Coney, L., D. Kolev, Summers, DJ, C. MacWaters, Jones, A., Clark I, P. Cooke, Witte, H., Clark D, Iaciofano, A., Courthold M, Lombardi, A, Lucchini, G., Alexander, J, Hare, R., Capponi, M, Yoshimura K, Capponi, M., Matsushita, T., D. Neuffer, Parisi M, Soler FJP, Lintern, A., Fletcher, R., Cecchet, G, G. Lucchini, Cadoux F, Vretenar, M, Y. Torun, Cremaldi, LM, Vretenar, M., A. Sato, Bross, A. D. (Alan D.), Paleari, F., Zisman, MS, Smith, P, Roberts, T. J., Petitjean, C., MacWaters, C., Moss, A, Ferri F, M. Takahashi, Seviour R, K. Tilley, Palmer, R.B., Kasey, V., Neuffer, D., Kafka G, Littlefield, M, R. Sandstrom, A. D. Bross, Rochford, J.H., Fish, A, Wilson A, Clark, D, Vankova-Kirilova, G, F. Paleari, Kyberd P, Cirillo, A., Rimmer, R. A., Roberts, TJ, Haseroth, H, D. J. Summers, Pasternak, J., S. Virostek, Clark, I, G. Vankova Kirilova, C. Rogers, W. Lau, de Bari, A., Strati F, Bertoni, R., M. Ellis, Rochford JH, Geer, S., Suzuki, S, Blondel, A, Kim, Y.K., Kahn S, Preece R, Yang X, A. Oates, Karadzhov, Y., Jones, A, P. Kyberd, Capponi M, Sashalmi, T, Yang S, Sashalmi, T., A. Iaciofano, Gilardoni, S., Moretti, A., P. Owens, Hills M, Paleari F, Matsushita T, Snopok, P, B. Martlew, Cadoux, F, Grichine, V, Robinson M, Green MA, L. Coney, Masciocchi, F., Blot, S., Cremaldi LM, Lee, K., Cecchet G, McKigney E, Bravar, U, G. Charnley, S. Fayer, Kahn, S, Sato, A., Tunnell, C. D., Bari, A de, Ivaniouchenkov, Y., Preece, R., Jamdagni, A, I. Russinov, Baynham, D. E., Torun, Y., R. A. Rimmer, Manfredini A, Owens, P, J. Pasternak, A. DeMello, A. Jones, Virostek S, Sandstrom R, S. Ricciardi, Bene, P, Leaver, J, Spensley, W., Bravar, U., Karadzhov, Y, Nebrensky, J. J., P. Gruber, Fletcher, R, Y. K. Kim, Gallardo J, Matsushita, T, Martlew, B, Seviour, R., Wang, L., Zisman MS, Soler, F. J. P., Nichols A, Palmer, R. B., G. Gregoire, Harrison, P., Tonazzo, A., Rogers, C, Manfredini, A., M. Bogomilov, Heidt, C, Bradshaw, TW, Booth, C N, D. Colling, T. Matsushita, Kahn, S., Hare, R, Tortora L, J. Back, Nelson, C, A. Fish, Fukui, Y, Li, D., Graulich, J-S, P. Snopok, K. Long, Green, M. A., Mullacrane I, Janot, P., Wisting, H., White, C., R. Preece, Bravar U, Apsimon, R, Masciocchi, F, Hanlet, P, Ellis M, Kuno, Y., Kasey, V, H. Sakamoto, DE BARI, ANTONIO, Lintern A, Cummings, M.A.C., Khaleeq, M, Robinson, M, Booth, C.N., Gallardo, J, Roberts TJ, Griffiths S, Preece, R, Vankova Kirilova G, Apsimon R, Apsimon, R., Summers, D. J., S. Kahn, Overton, E., Gruber, P., Lau, W., Gruber, P, Sanders, D A, PARISI, Mario, M. Bonesini, Edgecock, R., F. Filthaut, Tarrant, J., Kuno Y, Dobbs, A, F. Ferri, Palmer RB, Bertoni, R, Huang, D, Ricciardi, S, Parisi, M., York, S, Summers, D.J., F. Masciocchi, Howlett, L., J. S. Graulich, P. Hanlet, Yang, S, M. Popovic, Ishimoto, S, Bertoni R, Cirillo, A, Gregoire G, Apollonio, M, Boyd, S., Janot P, Orestano D, Leaver, J., E. Overton, Clark, D., Hanson, G. G., Yang, X, Back, J., Sanders, DA, T. W. Bradshaw, Martlew, B., J. J. Nebrensky, Coney, L, Gruber P, Bonesini, M., Y. Onel, Sanders, D.A., I. Clark, C. N. Booth, Cobb, J. H., Beuselinck R, G. Barber, Hills, M., S. Suzuki, Yoshida M, Sashalmi T, F. Pastore, Walaron, K, Soler, F J P, Paleari, F, A. Moretti, Russinov I, Geer S, Drumm P, Green, M A, Bradshaw TW, Sato, A, Karadzhov Y, Watson S, Alekou A, Yoshimura, K., Blondel, A., Mullacrane, I, A. Manfredini, M. Yoshida, Collomb N, M. Capponi, Sakamoto H, Dornan P, Kaplan, DM, Heidt, C., MICE Collaboration, Bradshaw, T.W., H. Witte, Overton, E, Harrison, P. F., Bross AD, Moretti A, Alexander J, Beuselinck, R., McKigney, E, Kaplan, D.M., DeMello, A, Takahashi M, Palladino V, Fish A, Hanson GG, Lintern, A, Summers, D J, Bross, A.D., Griffiths, S, Smith P, Ishimoto S, Drumm, P., Green, MA, Adams, D, H. Wisting, S. Boyd, T. Sashalmi, Adey D, Adey, David, Ph.D., I. Mullacrane, M. A. Green, Fukui, Y., Bonesini M, Alekou, A, Sakamoto, H., Charnley, G, Tonazzo, A, Moss, A., H. Kirk, Snopok P, MacWaters C, Mullacrane, I., D. M. Kaplan, Sandstrom, R., Huang, D., M. Robinson, Oates A, Collomb, N, Charnley G, M. Apollonio, Robinson, M., Popovic M, R. Bertoni, Owens P, Cadoux, F., Soler, FJP, Hanlet P, York S, Tunnell, CD, Tunnell, C.D., Colling, D, Hare R, D. Clark, Nicholson, R, Sanders DA, Ricciardi, S., Nicholson R, K. Hanke, P. Hodgson, Mori, Y, Long, K., Takahashi, M, T. J. Roberts, Petitjean C, DeMello, A., D. E. Baynham, Baynham DE, Gallardo, J., Zheng, SX, X. Yang, Hanke K, Hanke, K., Blot S, J. H. Rochford, Tilley K, Carlisle T, Clark, I., Bene, P., Overton E, Khaleeq M, Baynham, D.E., Pastore, F., Blondel A, Bari, A. de, Hayler T, Rogers, C., Booth, CN, R. Hare, S. Yang, Blackmore, V, Dobbs, A., Nebrensky, JJ, Suzuki S, Bross, A D, Ellis, M., Bradshaw, T W, Mazza, R., Blot, S, M. S. Zisman, Fayer S, Baynham, D E, Watson, S., Dornan, P, Gschwendtner, E., Greenwood, S, Khaleeq, M., L. Wang, Booth CN, P. Drumm, Tsenov, R, R. Tsenov, Yoshida, M, J. H. Cobb, Greenwood S, Palmer, R B, J. Tarrant, Barber, G., Collomb, N., Jamdagni, A., C. White, T. Yano, Vankova-Kirilova G, Moretti, A, MacWaters, C, K. Lee, Yoshida, M., R. Seviour, Russinov, I., S. X. Zheng, Rayner M, Cobb JH, Oates, A, D. Orestano, Orestano, D., Verguilov, V., Sakamoto, H, Tarrant, J, Edgecock, R, Lee K, Ferri, F, Neuffer, D, L. Tortora, Spensley, W, Adey, D, Yano, T., Alekou, A., Hart TL, Wisting H, Popovic, M, Roberts, T J, Y. Kuno, Kirk H, Adams D, C. Petitjean, Tilley, K, Back, J. J., Gschwendtner, E, F. Strati, Booth, C. N., G. G. Hanson, S. Watson, Cobb, J.H., Rochford, JH, Garoby R, Blackmore, V., A. Cirillo, A. Blondel, Huang D, Hodgson, P, Barber G, Green, M.A., Barclay P, Walaron K, Garoby, R, Savidge T, Freemire B, Smith, P., Wang L, Hanlet, P., Cline D, Pasternak, J, Barclay, P., Lucchini, G, N. Collomb, Zheng, S X, Watson, S, D. Adey, Hart, T.L., Coney L, A. Nichols, Ricciardi S, Freemire, B, A. Lombardi, Roberts, T.J., Boyd, Steve B., Torun, Y, Tarrant J, Gschwendtner E, P. Janot, Leaver J, Long K, Spensley W, Bross, AD, Fayer, S., Hart, T L, Takahashi, M., Kim YK, Cobb, J H, S. Ishimoto, Littlefield M, Tortora, L., Sanders, D. A., Rogers C, Tsenov, R., S. Gilardoni, Alexander, J., Gregoire, G., Kirk, H., S. Geer, S. Greenwood, PALLADINO, VITTORIO, Kolev D. +815 morecore +2 more sources
