Results 41 to 50 of about 156,415 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Thermal Characteristic and Analysis of Electro-Hydrostatic Actuator

IEEE Access
Electro-hydrostatic actuators (EHAs) are widely utilized due to their superior integration and high power-to-weight ratio. However, the elimination of a centralized oil source in EHAs restricts the cooling capacity of the system, leading to potential ...
Jiahui Liu, Hao Huang, Yaowen Ge, Xiaoli Zhao, Wenxiang Deng, Guangfa Gao, Jianyong Yao   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Research on Temperature Change Law and Non-Uniform Distribution Characteristics of Electromagnetic Control Roll Based on Rotating Heat Flow

Machines
The uniform temperature distribution on the surface of the electromagnetic control roll (ECR) has a great impact on the quality of the strip; therefore, temperature control is essential.
Shuaishuai Zheng, Tingsong Yang, Tieheng Yuan, Wenquan Sun, Ankang Shen, Shuo Fan   +5 more
doaj   +1 more source

The Reduction Design for Structure Borne Noise of Electronic Cabinet on Shipboard Considering Cooling Performance [PDF]

한국정밀공학회지, 2017
An air cooling system using an axial flow fan is generally applied in an electronic cabinet on shipboard. However, cases that apply a water cooling system or a mixture of water cooling and an air cooling system are gradually increased by applying the ...
Young Min Lee, Jeong Hoon Park, Kwan Soo Jeon, Byung Jun Kim, Chul Hyun Kwak   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Effect of Impellers on the Cooling Performance of a Radial Pre-Swirl System in Gas Turbine Engines

Aerospace
Impellers are utilized to increase pressure to ensure that a radial pre-swirl system can provide sufficient cooling airflow to the turbine blades. In the open literature, the pressurization mechanism of the impellers was investigated. However, the effect
Wenjie Shen, Suofang Wang, Xiaodi Liang
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Performance Analysis of the Liquid Cooling System for Lithium-Ion Batteries According to Cooling Plate Parameters

Batteries, 2023
In this study, the effects of battery thermal management (BTM), pumping power, and heat transfer rate were compared and analyzed under different operating conditions and cooling configurations for the liquid cooling plate of a lithium-ion battery.
Nayoung You, Jeonggyun Ham, Donghyeon Shin, Honghyun Cho   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source