Results 131 to 140 of about 3,662,691 (338)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cooperation in changing environments: Irreversibility in the transition to cooperation in networks

, 2013
In the framework of the evolutionary dynamics of the Prisoner's Dilemma game on complex networks, we investigate the possibility that the average level of cooperation shows hysteresis under quasi-static variations of a model parameter (the "temptation to
Floría, L. M., Gracia-Lázaro, C., Gómez-Gardeñes, J., Moreno, Y.   +3 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Inferring internal states across mice and monkeys using facial features

Nature Communications
Animal behaviour is shaped to a large degree by internal cognitive states, but it is unknown whether these states are similar across species. To address this question, here we develop a virtual reality setup in which male mice and macaques engage in the ...
Alejandro Tlaie, Muad Y. Abd El Hay, Berkutay Mert, Robert Taylor, Pierre-Antoine Ferracci, Katharine Shapcott, Mina Glukhova, Jonathan W. Pillow, Martha N. Havenith, Marieke L. Schölvinck   +9 more
doaj   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Identifying pathways to achieve diverse objectives of the National Essential Diagnostics List: developing an assessment framework based on field studies in Cambodia, Indonesia, Lao PDR, and the Philippines

Tropical Medicine and Health
Background Access to essential in vitro diagnostics is limited in many low- and middle-income countries (LMICs). To address this, the World Health Organization introduced the Model List of Essential In Vitro Diagnostics (EDL) in 2018, encouraging member ...
Shogo Kanamori, Yuriko Egami, Eiichi Shimizu, Shinsuke Miyano, Antonio F. dela Resma Villanueva, Naofumi Hashimoto, Hiroyuki Kiyohara, Masataro Norizuki, Manami Uechi, Kyoko Koto-Shimada, Yasunori Ichimura, Masami Fujita   +11 more
doaj   +1 more source

SOME ISSUES OF INTERNATIONAL LEGAL COOPERATION IN COMBAT AGAINST CORRUPTION

, 2022
Daler Valijonov
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

TRADE AND COMPETITIVE COOPERATION OF THE EU WITH THE MAJOR INTERNATIONAL INTEGRATION GROUPINGS

, 2020
Olena Zayats
openalex   +2 more sources

Networked Governance in Transnational Cooperation and Politics: Responding to COVID-19 Pandemic Along Thai-Laos Cross-Border Communities

, 2023
Visara Kraiwatanapong, Yared Akarapattananukul   +1 more
openalex   +2 more sources