Results 71 to 80 of about 20,411 (265)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Baltic Journal of Economic Studies, 2019 The purpose of the paper is to outline the legal framework for the development of Ukrainian- Moldovan, Ukrainian-Slovak and Ukrainian-Romanian transborder regions (TBR), in particular in the context of intergovernmental agreements, national legislation ...
Liudmyla Chobal, Mariya Lalakulych
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Regional environmental governance: the NAFTA case
Agricultural Economics (AGRICECON), 2012 The United Nations Conference on Environment and Development held in Rio de Janeiro in 1992 elaborated the idea of sustainable development. A comprehensive document called the Agenda 21 provided an explanation how to achieve a sustainable economic ...
Eva CIHELKOVÁ
doaj +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Revista Vasca de Administración Pública, 2016 The complexity of the framework of the Autonomous Community of the Basque Country calls for the development of mechanisms of collaboration between administrations since the shared competences are numerous, specially between the Basque Government and the ...
Sergio Pérez Castaños +1 more
doaj +1 more source
La cooperación intergubernamental en el Estado autonómico: situación y perspectivas [PDF]
Revista d'Estudis Autonòmics i Federals, 2012 As proclaimed by the Spanish Constitutional Court at an early stage, the existence of cooperative relations is inherent to the State of Autonomies, yet cooperation among the various regional authorities has been scarce in Spain, both qualitatively and ...
José Gabriel Ruiz González
doaj
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source