Results 61 to 70 of about 1,077,798 (264)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

open access: yesAdvanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries   +25 more
wiley   +1 more source

STATE AND EUROPEAN COOPERTIVE CULTURE [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
In this article we want to present the defining features of credit cooperatives as an essential component of economic and social reality of the modern world.
LILIANA - AURORA CONSTANTINESCU
doaj  

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

open access: yesAdvanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang   +7 more
wiley   +1 more source

The Relationship between Risk, Capital and Efficiency: Evidence from Japanese Cooperative Banks [PDF]

open access: yes
The risk-capital positions of Japanese banks have been under tension throughout the 1990s. However, existing theory on the determinants of bank risk-taking still remains limited and the evidence is conflicting. Most studies concentrate on US and European
Tara Deelchand, Carol Padgett
core  

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

open access: yesAdvanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang   +5 more
wiley   +1 more source

Announcing a correspondence course on leadership : a project of the Virginia Cooperative Extension Service

open access: yes, 1983
A brochure announcing a new correspondence course offered through the Cooperative Extension ...
Virginia Cooperative Extension Service
core  

Virginia Cooperative Extension Volunteer Screening Guidelines

open access: yes, 2020
Frequently asked questions for Virginia Cooperative Extension volunteers.

core  

Publishing cooperative and work-integrated education literature: The Asia-Pacific Journal of Cooperative Education [PDF]

open access: yes, 2012
The Asia-Pacific Journal of Cooperative Education (APJCE) was founded in 1999, with the first volume published in 2000. The journal strongly adhered to the philosophy of having freely and readily accessible information, and opted to be a free, fully ...
Zegwaard, Karsten E.
core  

Norges Banks oppgjørssystem : Årsrapport 2021 [PDF]

open access: yes, 2022
Formålet med Norges Banks oppgjørssystem (NBO) er å gjennomføre sikre og effektive oppgjør av betalinger mellom banker som har konto i Norges Bank.

core  

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

open access: yesAdvanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun   +12 more
wiley   +1 more source

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