Results 51 to 60 of about 9,832,736 (309)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The evolution of nursing in Australian general practice: a comparative analysis of workforce surveys ten years on [PDF]

, 2014
This article describes the current demographic and employment characteristics of Australian nurses working in general practice, and explores trends in their role over time. Abstract: Background Nursing in Australian general practice has grown rapidly
Samantha A.M. Young, Rajneesh Kaur, Salamonson, Y, Kaur, R ; https://orcid.org/, Samantha AM Young, Halcomb, EJ, Patricia M Davidson, Davidson, Patricia M., Elizabeth J Halcomb, Patricia M. Davidson, Kaur, R, Halcomb, Elizabeth, Davidson, PM ; https://orcid.org/, Elizabeth J. Halcomb, Young, SAM, Yenna Salamonson, Young, Samantha A., Davidson, PM, Salamonson, Yenna (R8521), Kaur, Rajneesh   +19 more
core   +2 more sources

Double helix of research and practice—developing a practice model for crisis resolution and home treatment through participatory action research

International Journal of Qualitative Studies on Health & Well-Being, 2010
Over the last five years Crisis Resolution/Home Treatment (CR/HT) teams have been established in Norway. These teams provide an alternative to in-patient acute care services offering assessment as well as direct care.
Marit Borg, Bengt Karlsson, Hesook Suzie Kim   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Student experiences in a Sino-foreign cooperative undergraduate nursing programme: a qualitative study

Cogent Education
Background Sino-foreign cooperative undergraduate programmes are an important form of internationalised nursing education in China, yet little qualitative research has examined how students experience them in practice.Objectives To explore how ...
Yunyun Dai, Xuelei Chen, Yan Gao
doaj   +1 more source

Bridging the theory-practice gap in Iranian emergency nursing education

ARYA Atherosclerosis, 2018
BACKGROUND: The theory-practice gap is one of the important challenges of treatment, health, and educational systems. It is affected by different factors like students, teachers, and the clinical environment.
Shima Safazadeh, Alireza Irajpour, Nasrollah Alimohammadi, Fariba Haghani   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice. [PDF]

, 2015
BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease.
Peat, George, Steffen E Petersen, Douglas G Altman, Perel, P, Petersen, SE, Deeks, Jonathan J, Peter Croft, Van Der Windt, Danielle A, Richard D Riley, Hay, AD, Peat, G, Croft, Peter, Altman, DG, Van Der Windt, DA, Richard J Stevens, Harry Hemingway, Riley, Richard D; id_orcid, Michael Sharpe, LeResche, Linda, Linda LeResche, Roberts, Ian, George Peat, Croft, P, Kate M Dunn, Hemingway, Harry, Altman, Douglas G, Stevens, Richard J, Stevens, RJ, Jonathan J Deeks, Dunn, Kate M, Deeks, JJ, Sharpe, M, Adam Timmis, LeResche, L, Timmis, A, Hay, Alastair D, Von Korff, M, Sharpe, Michael, Dunn, KM, Michael Von Korff, Perel, Pablo, Riley, RD, Ian Roberts, Von Korff, Michael, Alastair D Hay, Pablo Perel, Petersen, Steffen E, Riley, Richard D, Danielle A Van Der Windt, Timmis, Adam, Hemingway, H, Roberts, I   +51 more
core   +2 more sources