Results 41 to 50 of about 863,819 (307)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Impact Statements. Virginia Cooperative Extension [PDF]

open access: yes, 2020
A collection of impact statements from Virginia State University and Virginia Tech’s Virginia Cooperative Extension program concerning many different projects done with Virginia rural and urban farmers.
Nartea, Theresa J.
core  

THE IMPLEMENTATION OF RISK MANAGEMENT AND ITS EFFECT ON GOOD COOPERATIVE GOVERNANCE AND SUCCESS

open access: yesJournal of Indonesian Economy and Business, 2018
The Cooperative success must be support by Good Cooperative Governance and implementation of risk management. This study identifies risk management, especially in savings and loan cooperatives, and to test and prove empirically the effects of the ...
Sugiyanto, Anggi Andriani Rahayu
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Virginia Cooperative Extension Pledge Form [PDF]

open access: yes, 2014
This is a two page gift/pledge form in support of Virginia Cooperative ...

core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

An object model development for the UK automated compliance checking [PDF]

open access: yes, 2013
Approving building designs against existing UK building regulations manually is a time consuming and tedious process. As the architecture engineering construction (AEC) industry moves from 2D CAD drawings to more semantically rich building information ...
Malsane, S.   +4 more
core  

Integral Fuzzy Sliding Mode Impedance Control of an Upper Extremity Rehabilitation Robot Using Time Delay Estimation

open access: yesIEEE Access, 2019
Robot-assisted cooperative rehabilitation training has shown superiority in helping the individuals with motion impairment problems to regain their motor functions.
Qingcong Wu   +3 more
doaj   +1 more source

Cooperative compliance programmes

open access: yes, 2021
This study examines which organisations participate in cooperative compliance programmes(CCPs) and why by comparing large organisations in the Netherlands that do and do notparticipate in them. We use data from surveys conducted among representatives of largeorganisations and their Netherlands Tax and Customs Administration (NTCA) accountmanagers ...
Goslinga S.   +3 more
openaire   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

open access: yesAging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho   +4 more
wiley   +1 more source

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