Results 161 to 170 of about 904,877 (286)

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

A cooperative learning framework for the integration of metabolomic data from multiple cohorts and common phenotype identification. [PDF]

Comput Struct Biotechnol J
Salanon E, Jules E, Comte B, Boccard J, Pujos-Guillot E.   +4 more
europepmc   +1 more source

Understanding motivation for implementing cooperative learning methods: a value-based approach. [PDF]

Soc Psychol Educ, 2022
Filippou D, Buchs C, Quiamzade A, Pulfrey C.   +3 more
europepmc   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

The effect of cooperative learning approach with concept maps on nursing students' knowledge acquisition on symptom management in cancer patients: a randomized controlled trial. [PDF]

BMC Med Educ
Kahraman BB, Acun A, Bilgiç S.
europepmc   +1 more source

The Community of Practice: A Method for Cooperative Learning of Occupational Health and Safety Inspectors. [PDF]

Eur J Investig Health Psychol Educ, 2021
Gilardi L, Marino M, Fubini L, Bena A, Ferro E, Santoro S, Tosco E, Pasqualini O.   +7 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

A narrative analysis of learning to teamwork in youth sport: a sociocultural perspective on communication and cooperative learning. [PDF]

Front Sports Act Living
Arumí-Prat J, Pla-Campas G.
europepmc   +1 more source

The Efficiency of Cooperative Learning in Physical Education on the Learning of Action Skills and Learning Motivation. [PDF]

Front Psychol, 2021
Yang C, Chen R, Chen X, Lu KH.
europepmc   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source