Results 41 to 50 of about 565,896 (296)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

THE DUBLIN PRINCIPLES OF COOPERATION [PDF]

Alcohol and Alcoholism, 1997
In this issue of Alcohol and Alcoholism, we publish, as a Special Commentary, the text of a document concerning the cooperation between the alcoholic beverage industry, governments, scientific researchers and the public health community in the furtherance of public knowledge about alcohol and the prevention of its misuse, which was drawn up by a group ...
K. F. TIPTON, A. A.-B. BADAWY
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Commodity tax competition and industry location under the destination- and the origin-principle [PDF]

We develop a model of commodity tax competition with monopolistically competitive internationally mobile firms, transport costs, and asymmetric country sizes.
BEHRENS, Kristian, HAMILTON, Jonathan H., OTTAVIANO, Gianmarco I.P., THISSE, Jacques-François   +3 more
core   +3 more sources

TINDAK TUTUR DALAM PROSES JUAL BELI DI PASAR TRADISIONAL SURAKARTA

Prasasti: Journal of Linguistics, 2016
The objectives of this research are: to describe the forms of speech acts and to show the most dominant speech act and the reasons of its use; and to describe and define the politeness principle found in the the goods sale and purchase process at ...
Ririn Linda Tunggal Sari, Sumarlam Sumarlam, Dwi Purnanto   +2 more
doaj   +1 more source

Exploring cooperative game mechanisms of scientific coauthorship networks

, 2018
Scientific coauthorship, generated by collaborations and competitions among researchers, reflects effective organizations of human resources. Researchers, their expected benefits through collaborations, and their cooperative costs constitute the elements
Li, Jianping, Li, Miao, Xie, Zheng
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

PENYIMPANGAN PRINSIP KERJA SAMA DAN PRINSIP KESOPANAN WACANA KARTUN PADA BUKU POLITIK SANTUN DALAM KARTUN KARYA MUHAMMAD MICE MISRAD

Jurnal Penelitian Humaniora, 2015
This study deals with the violation of cooperative politeness principle of cartoon discourse found in Politik Santun Dalam Kartun by Misrad. The objectives of the study are as follows: (1) to identify the violation of cooperative principle; (2) to ...
Azizah Malikha Yunitawati, Abdul Ngalim, Atiqa Sabardila   +2 more
doaj  

A STUDY COOPERATIVE PRINCIPLE IN INDONESIAN POLITICAL LANGUAGE

Kajian Linguistik dan Sastra, 2015
This study scrutinizes Indonesian Political Language from cooperative principle perspective. The object of the study is Indonesian political language in words, phrase, clause, sentence, or discourse taken from Indonesian newspapers. The data was analyzed
Norwanto Norwanto
doaj   +1 more source