Results 61 to 70 of about 84,810 (268)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Antibacterial Mechanism of Zanthoxylum bungeanum Extract against Shewanella putrefaciens
Shipin gongye ke-jiThe aim of this study was to elucidate the antibacterial mechanism of Zanthoxylum bungeanum extract against Shewanella putrefaciens. The effects of the extract on bacterial growth, cell wall integrity, membrane permeability, cellular morphology, and ...
Huijuan ZHAO +4 more
doaj +1 more source
ENVIRONMENTAL-ECONOMIC ACCOUNTING AND ASSESS THE EFFECTIVENESS OF ENVIRONMENTAL MANAGEMENT
Вестник Северо-Кавказского федерального университета, 2022 The article discusses the reflection of natural assets in national accounts meso- and megaeconomic level. The peculiarities of valuation of natural assets as a complex ecological-economic categories, which should be oriented not on the market, and the ...
Anatoly Belousov, Lilia Blizno
doaj
From misconceptions of the “financial diet” to the misconceptions of the “decoding” of Belarus
RUDN Journal of Economics, 2018 The consequences of the policy of the “financial diet” in the development of socialeconomic processes in Belarus are assessed. The recognition of the erroneous provisions of the public finance reform in Belarus is analyzed. The conformity of the ideas of
A G Zlotnikov
doaj +1 more source
Young Member Programs for Cooperatives [PDF]
The overall objective of this study is to provide cooperative decision makers with effective strategies for developing young member programs in local cooperatives.
Schomisch, Thomas P., Gray, Thomas W.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Cooperatives and Development: Lessons from the Punjab Experience [PDF]
Traditionally, cooperatives have been expected to serve a broad set of sociopolitical and economic objectives ranging from self-help and grass-root participation to welfare and distribution, including economies of scale and social control over resource ...
Zulfiqar Ahmad Gill, Khalid Mustafa
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Structural Change and Performance of Grain Marketing Cooperatives [PDF]
The U.S. grain marketing system has undergone many structural changes in the 1980s. In no part of the system has structural change been more far-reaching and extensive than in farmer-owned cooperatives.
Dahl, Reynold P.
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source