Results 161 to 170 of about 60,064 (306)

Designing Cooperative Molecular Glues for FKBP12-MAPRE1 with Enhanced-Sampling Molecular Dynamics Simulations. [PDF]

J Am Chem Soc
Chen SY, Solazzo R, Fouché M, Roth HJ, Dittrich B, Riniker S.   +5 more
europepmc   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Deep learning uncovers hidden power of low-affinity motifs. [PDF]

Cell Genom
Bower G, Kvon EZ.
europepmc   +1 more source

Dual‐Alloy Exsolution in Fe‐Based Perovskite Anodes for High‐Performance Direct Ammonia Solid Oxide Fuel Cells

Advanced Functional Materials, EarlyView.
Dual FeCo and FeNi alloy nanoparticles are exsolved from a multi‐doped Fe‐based perovskite anode for high‐performance direct ammonia solid oxide fuel cells. The dual‐alloy surface coordinates electronic structure modulation and nanoparticle morphology control, providing abundant reaction sites and complementary catalytic functions for NH3 decomposition,
Jungseub Ha, Sehun Choi, Sanghwa Jeong, Minguk Kwak, Daehwan Kim, Jongcheol Gang, Taeyeol Jeon, Sujin Kim, Yongju Yun, Won Bae Kim   +9 more
wiley   +1 more source

pH-Dependent Stability and Cooperativity of Protein Unfolding from Differential Scanning Calorimetry Using FitFoldData. [PDF]

Biomolecules
Yeritsyan K, Uversky V, Badasyan A.
europepmc   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source

Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain family. [PDF]

Nat Commun
Cain B, Wasmund C, Rowan FC, Gebelein B.
europepmc   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

The non-canonical CDK2 activator SPY1 uses separable mechanisms to activate phosphorylated and unphosphorylated CDK2. [PDF]

Biochem J
Fawcett LP, Levinson NM.
europepmc   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source