Results 111 to 120 of about 404,392 (246)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Complexes to coordinate calcium

The Journal of Cell Biology, 2005
![Graphic][1] EGFR (small dots) and IP3R1 (large dots) colocalize at PM–ER junctions.On [page 657][2], Hur et al. show that signaling complexes on the plasma membrane and ER, and two different signals, unite to coordinate calcium release.Many signaling pathways, sometimes ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Synthesis of mono and hetero-bi nuclear lanthanum (III) and europium (III) complexes of 2-hydroxy-5-sulfobenzoic acid and 1,10-phenanthroline: luminescence and magnetic studies

Journal of Materials Science: Materials in Engineering
The resurgence of interest in lanthanide coordination complexes due to their diverse applications has been increasing for past decade. These lanthanide complexes have found applications such as catalysts, sensors, optoelectronics, light sources, and ...
Rukhsana J. Wani, Arshad Hussain, Mehraj Ud Din Sheikh, Mohd Nadeem Bukhari, Maryam Fatima, Gazunfor Ali   +5 more
doaj   +1 more source

Coordination compounds of indium, gadolinium, and erbium nitrates with low urea content

Тонкие химические технологии
Objectives. To date, compounds of rare earth nitrates with urea in a ratio of 1:4 and indium in a ratio of 1:6 have been synthesized and structurally characterized.
E. V. Savinkina, I. A. Karavaev, E. K. Bettels, G. A. Buzanov, A. S. Kubasov   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Complexity, Coordination Dynamics and the Urban Landscape

Buildings
Similar to living complex systems, cities are composed of a huge number of interacting parts, each with its specific properties, rhythm, etc., that, by means of self-organization, give rise to a functioning complex system.
Juval Portugali
doaj   +1 more source

Smart bistable coordination complexes

Smart Molecules
AbstractSmart molecules have attracted increasing attention due to their transformative role in creating the next generation of smart structures and devices. Smart bistable coordination complexes are a class of functional complexes which have two stable states that can be reversibly switched in response to external stimuli. Such bistable molecules play
Xiong Xiao, Zong‐Ju Chen, Russell J. Varley, Cheng‐Hui Li   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source