Results 21 to 30 of about 211,525 (240)

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Journal of Experimental Medicine, 2020
Heterozygous missense mutations in COPA underlie constitutive interferon signaling through STING, thereby defining a novel type I interferonopathy and emphasizing the importance of the ER–Golgi axis in interferon homeostasis.
A. Lepelley, M. Martin-Niclós, M. Le Bihan, J. Marsh, C. Uggenti, G. Rice, V. Bondet, D. Duffy, Jonny Hertzog, J. Rehwinkel, S. Amselem, Siham Boulisfane-El Khalifi, M. Brennan, Edwin Carter, L. Chatenoud, S. Chhun, Aurore Coulomb l’Hermine, Marine Depp, M. Legendre, K. Mackenzie, J. Marey, C. McDougall, K. McKenzie, T. Molina, B. Neven, L. Seabra, C. Thumerelle, M. Wislez, N. Nathan, N. Manel, Y. Crow, M. Frémond   +31 more
semanticscholar   +1 more source

Sequence-based Functional Metagenomics Reveals Novel Natural Diversity of Functional CopA in Environmental Microbiomes

bioRxiv, 2022
Exploring natural diversity of functional genes/proteins from environmental DNA (eDNA) in a high-throughput fashion remains challenging. In this study, we developed a sequence-based functional metagenomics procedure for mining the diversity of copper ...
Wenjun Li, Likun Wang, Xiaofang Li, Xin Zheng, Michael F. Cohen, Yong-xin Liu   +5 more
semanticscholar   +1 more source

La última copa [PDF]

Assaig de teatre: revista de l'Associació d'Investigació i Experimentació Teatral, 1998
Pinter, Harold
core   +2 more sources

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

bioRxiv, 2020
Pathogenic COPA variants cause a Mendelian syndrome of immune dysregulation with elevated type I interferon signaling1,2. COPA is a subunit of coat protein complex I (COPI) that mediates Golgi to ER transport3.
Zimu Deng, Zhenlu Chong, Christopher S. Law, Kojiro Mukai, Frances O. Ho, T. Martinu, B. J. Backes, W. Eckalbar, T. Taguchi, A. Shum   +9 more
semanticscholar   +1 more source

Identification of COPA as a potential prognostic biomarker and pharmacological intervention target of cervical cancer by quantitative proteomics and experimental verification

Journal of Translational Medicine, 2022
Cervical cancer is the most fatal gynecological carcinoma in the world. It is urgent to explore novel prognostic biomarkers and intervention targets for cervical cancer.
Huiqiong Bao, Xiaobin Li, Zhi-xin Cao, Zhihong Huang, Li Chen, Mingbin Wang, Jiali Hu, Wenting Li, Hongwei Sun, Xuedong Jiang, P. Mei, Huawen Li, Ligong Lu, Meixiao Zhan   +13 more
semanticscholar   +1 more source

Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance [PDF]

, 2016
Background A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior.
Purdy, Ashley M., Sun, Simon D., Walsh, Gregory S.   +2 more
core   +2 more sources

CoPa: General Robotic Manipulation through Spatial Constraints of Parts with Foundation Models [PDF]

IEEE/RJS International Conference on Intelligent RObots and Systems
Foundation models pre-trained on web-scale data are shown to encapsulate extensive world knowledge beneficial for robotic manipulation in the form of task planning.
Haoxu Huang, Fanqi Lin, Yingdong Hu, Shengjie Wang, Yang Gao   +4 more
semanticscholar   +1 more source

Characterization of multicopper oxidase CopA from Pseudomonas putida KT2440 and Pseudomonas fluorescens Pf-5 : Involvement in bacterial lignin oxidation [PDF]

, 2018
CopA is a protein formed as part of a copper resistance operon in Pseudomonas syringae pv tomato, but CopA has also been identified from gene library screening as a potential lignin-oxidising enzyme.
Bugg, Timothy D. H., Granja-Travez, Rommel Santiago   +1 more
core   +1 more source

Mutations in troABCD against Copper Overload in a copA Mutant of Streptococcus suis

Applied and Environmental Microbiology, 2022
Metal homeostasis plays a critical role during the process of bacterial infection. We identified three important potential candidate genes involved in maintenance of intracellular copper homeostasis.
Xia Yang, Wei Peng, Yanna Wang, K. Yan, Zewen Liu, Ting Gao, Keli Yang, Wei Liu, R. Guo, Chang Li, Huan-chun Chen, Yong-xiang Tian, Danna Zhou, Weicheng Bei, F. Yuan   +14 more
semanticscholar   +1 more source

Comportamento da laranjeira 'Pêra' sobre cinco porta-enxertos em ecossistema de tabuleiros costeiros, Umbaúba-SE Behavior of Pera orange on five different roostocks in Brazilian coastal tableland ecosystem

Revista Brasileira de Fruticultura, 2004
Em experimento instalado em 1984 no Campo Experimental de Umbaúba-SE, com delineamento em blocos casualizados, avaliou-se a potencialidade da laranjeira 'Pêra' [Citrus sinensis (L.) Osb.], clone D6, enxertada sobre cinco porta-enxertos.
Roosevelt Menezes Prudente, Luiz Mário Santos da Silva, Almir P. da Cunha Sobrinho   +2 more
doaj   +1 more source