Results 31 to 40 of about 698,173 (286)

Sickle Cell Disease in African Newspapers: A Content Analysis of News Coverage of Burden, Genetic Counselling and Newborn Screening, 2006‐2023

eJHaem
Background Despite being the most common monogenic disease worldwide, there is a general lack of public awareness of sickle cell disease (SCD). Newspapers, which are widely accessible in Africa, are key to increasing awareness of health issues and ...
Bernard Appiah, Collins Annor, Julia Chukwu Boms, Fred Piel, Tara Tancred, Obiageli E. Nnodu, Josh Wright, Michelle Asiedu‐Danso, Alex Osei‐Akoto, Catherine Chunda‐Liyoka, Justin Pulford, Imelda Bates   +11 more
doaj   +1 more source

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

New Orleans Ten Years After The Storm: The Kaiser Family Foundation Katrina Survey Project [PDF]

, 2015
Ten years after Hurricane Katrina battered the Gulf Coast and the subsequent levee failure led to unprecedented destruction in New Orleans, the Kaiser Family Foundation teamed up with NPR to conduct a survey of the city's current residents.
Jamie Firth, Liz Hamel, Mollyann Brodie
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Coping strategies and their sociodemographic correlates: an analysis of Ecuatorian university student behavior

Frontiers in Education
IntroductionUniversity life presents numerous challenges that can affect students' emotional well-being and academic performance. Understanding how students cope with these challenges is essential for developing effective support strategies.MethodsThis ...
Dalila M. González-González, Luis F. Guerrero-Vásquez, Luis F. Guerrero-Vásquez, Jessica V. Quito-Calle   +3 more
doaj   +1 more source

A hybrid EKF and switching PSO algorithm for joint state and parameter estimation of lateral flow immunoassay models [PDF]

, 2012
This is the post-print version of the Article. The official published can be accessed from the link below - Copyright @ 2012 IEEEIn this paper, a hybrid extended Kalman filter (EKF) and switching particle swarm optimization (SPSO) algorithm is proposed ...
Du, M, Li, Y, Liu, X, Wang, Z, Zeng, N
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Living with debt after advice. A longitudinal study of people on low incomes [PDF]

, 2016
As a Foundation exploring the role of money and financial systems as a mechanism for the delivery of social goods and services, we seek to understand how individuals and systems interact, for good or ill; people’s experience of debt is an example. In the
Atfield, Gaby, Lindley, Robert M., Orton, Michael   +2 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Inbreeding estimates in human populations: Applying new approaches to an admixed Brazilian isolate. [PDF]

PLoS ONE, 2018
The analysis of genomic data (~400,000 autosomal SNPs) enabled the reliable estimation of inbreeding levels in a sample of 541 individuals sampled from a highly admixed Brazilian population isolate (an African-derived quilombo in the State of São Paulo).
Renan B Lemes, Kelly Nunes, Juliana E P Carnavalli, Lilian Kimura, Regina C Mingroni-Netto, Diogo Meyer, Paulo A Otto   +6 more
doaj   +1 more source