Results 121 to 130 of about 10,960 (241)

Cyclopropylamine‐Derived Distonic Iminium Radicals: Photoinduced Strategies in Chemo‐ and Stereo‐Selective Synthesis

open access: yesChemistry – A European Journal, EarlyView.
Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua   +3 more
wiley   +1 more source

A new era in business IT: exploring Microsoft 365 Copilot and the power of customisation through Copilot Studio

open access: yes
Die rasante Entwicklung der künstlichen Intelligenz (KI) hat in den letzten Jahren zu einer Vielzahl KI-gestützter Tools auf dem Markt geführt. Microsoft, einer der weltweit größten Akteure in der Informationstechnologie (IT), brachte als Reaktion auf ...
Coloini, Jana
core   +1 more source

MMAC-Copilot: Multi-modal Agent Collaboration Operating System Copilot [PDF]

open access: yes
Autonomous virtual agents are often limited by their singular mode of interaction with real-world environments, restricting their versatility. To address this, we propose the Multi-Modal Agent Collaboration framework (MMAC-Copilot), a framework utilizes ...
Shi, Zecheng   +6 more
core   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo   +4 more
wiley   +1 more source

Game copilot [PDF]

open access: yes
El proyecto "Game Copilot" se enfoca en potenciar la experiencia del jugador de videojuegos mediante un asistente virtual multiplataforma. Con el propósito de abordar la carencia de productos que atiendan las necesidades físicas, visuales y auditivas de ...
Pagella, Pablo Ezequiel
core  

Remote-copilot-center: Concept, Development and Validation

open access: yes, 2020
Remote-copilot-center: Concept, Development and ...
Schmid, Daniela
core  

How to Optimize Healthy Volunteer Screening and Enrolment in Clinical Trials: A Qualitative and Quantitative Approach to Evaluate Processes and Healthy Volunteers' Perceptions

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer   +10 more
wiley   +1 more source

Special Populations in Pivotal Clinical Trials: Eligibility and Supporting Evidence for Exclusion in EMA‐Authorised Medicines

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Evidence on the efficacy and safety of medicines supporting marketing authorization is largely derived from randomized controlled trials, yet these trials often exclude populations likely to use the medications in clinical practice. This study assessed eligibility of special populations, defined as pregnant and breast‐feeding individuals, elderly ...
Maja J. Jørgensen   +2 more
wiley   +1 more source

Free Your Summer with Copilot [PDF]

open access: yes
Microsoft Copilot currently offers access to GPT-4 and DALL·E 3 for most educators through institution credentials. Using Copilot, faculty can design a course aligned with program outcomes, varied assessment methods, and engaging classroom activities ...
Nemeroff, Adam, Torres, J.T.
core  

Corporate Social Responsibility and Corporate Tax Avoidance in Europe: Evidence From the Anti‐Tax Avoidance Directives

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the relationship between corporate social responsibility (CSR) and corporate tax avoidance (CTA) in the European Union, exploiting institutional variation arising from CSR disclosure regimes and the introduction of the Anti‐Tax Avoidance Directives (ATAD).
Alessandro Migliavacca
wiley   +1 more source

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