Results 61 to 70 of about 1,320,510 (242)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Pyramid structure for copy-move forgery detection
, 2016 碩士本論文提出一個被動式偵測影像是否遭到複製移動竄改的方法，不需原本未經竄改的影像也能夠偵測出被複製移動竄改的區塊，在一被複製移動竄改的影像中，假設在此影像中被複製移動竄改的區域為大於限定的範圍，對影像進行區塊分割，計算區塊中相互之間的關係，得到被竄改區域中的部分區塊，再藉由這些部分區塊往周圍以金字塔結構進行區塊比對至偵測被竄改區域的所有部分，此方法可降低影像中區塊之間比對的時間及次數。相較其他學者所提出的偵測方法，本論文之偵測方法相較於地毯式偵測的相同條件下，能有一樣的結果但大幅減少執行時間。This
陳怜穎;Chen, Ling-Ying
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Journal of Applied Informatics and ComputingIn recent years, more and more data has been created in digital form, allowing for easier control over storage and manipulation thanks to technological advancements.
Muhamad Masjun Efendi, Nukman Nukman
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Advancing Copy-Move Manipulation Detection in Complex Image Scenarios Through Multiscale Detector
IEEE AccessThis research presents a new approach for identifying instances of copy-move forgeries in digital images by utilizing the Multiscale Detector a Neural Network-based method, which serves as an image key-point detector and descriptor.
Anjali Diwan +2 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source