Results 61 to 70 of about 9,621,488 (249)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The role of genomic Copy Number Variation (CNV) in osteoporosis [PDF]

, 2012
Copy number variation (CNV) is a relatively novel source of genetic variation, involving the duplication or deletion of segments of genomic DNA (gDNA) sequence, thereby changing the original number of DNA copies.
Connolly, Kate
core  

Chromoanagenesis in Osteosarcoma

Biomolecules
Chromoanagenesis is a catastrophic genomic phenomenon involving sudden, extensive rearrangements within one or a few cell cycles. In osteosarcoma, the most prevalent malignant bone tumor in children and adolescents, these events dramatically alter the ...
Guozhuang Li, Nan Wu, Jen Ghabrial, Victoria Stinnett, Melanie Klausner, Laura Morsberger, Patty Long, Ezra Baraban, John M. Gross, Ying S. Zou   +9 more
doaj   +1 more source

The Porcine TSPY Gene Is Tricopy but Not a Copy Number Variant. [PDF]

PLoS ONE, 2015
The testis-specific protein Y-encoded (TSPY) gene is situated on the mammalian Y-chromosome and exhibits some remarkable biological characteristics. It has the highest known copy number (CN) of all protein coding genes in the human and bovine genomes (up
Anh T Quach, Olutobi Oluwole, William Allan King, Tamas Revay   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Common Genetic Variation and the Control of HIV-1 in Humans [PDF]

, 2009
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
Cirulli, Elizabeth T, Gunthard, HF, Thomas J. Urban, Andrew J. Mcmichael, Guenthard, Huldrych F., Gumbs, CE, Feng, S, Feng, Sheng, De Luca Andrea, McMichael, A. J, Obel, N., Miró Meda, José M. (José María), 1956-, O'Brien SJ, Haynes BF, Haynes, B. F, Ge, D., Letvin, Norman L., Jeremy J. Martinson, Martinson, J. J, Beckmann, J S, Smith, Jason P., Descombes P, Cozzi-Lepri, A, Jacobson, L P, Margolick, J B, Cirulli, E. T, Shianna, K V, Niels Obel, Ge Dongliang, Simon Mallal, Wolinsky, Steven M, Jacques S Beckmann, Urban TJ, O'Brien, S J, Antonarakis, S.E., Wolinsky, S. M, Bruno Ledergerber, Telenti, A., Urban, T.J., Ge, DL, Detels, R, Javier Martinez-Picado, Günthard, H F, Letvin, NL, Jason P. Smith, Zhang, Kunlin, Cirulli Elizabeth T., Colombo S, Colombo, S, McMichael, AJ, Feng S, McMichael, Andrew J., Joseph B. Margolick, Mussini, C., Cozzi-Lepri Alessandro, Sheng Feng, Descombes Patrick, Letvin NL, Goldstein, DB, Barton F. Haynes, Fellay, J., Jacobson, Lisa, Goldstein, D. B., Feng, S., Martínez Picado, Francisco Javier, Antonella Castagna, Haynes, BF, Telenti, A, Jacobson, L.P., Shianna, K.V., Fellay Jacques, Miro, José M, Antonarakis Stylianos E., Mcmichael, Andrew, David B Goldstein, Gumbs, C. E, Jacobson, Lisa P., Miro, José M., Jason P Smith, Miro, J.M., Cirulli, Elizabeth T., Antonarakis SE, Shianna, Kevin V, Easterbrook, P, Martinson, Jeremy J, Stylianos E Antonarakis, Gumbs, Curtis E, O'Brien, Stephen J, Mary Carrington, Mallal, S, Zhang, K, Curtis E. Gumbs, Castagna, A., Martinson, J J, Detels, Roger, Wolinsky SM, Easterbrook, Philippa, Haynes, Barton F, Letvin, N L, Letvin, N. L, Colombo, Sara, Martinez Picado J, Gumbs CE, Cozzi Lepri A, Haynes, B F, Smith, J P, Letvin, Norman L, Jacques Fellay, Ledergerber B, Telenti, Amalio, Carrington M, Dalmau, J., Mallal, Simon, De Luca, Andrea, Easterbrook Philippa, Martinez-Picado Javier, Wolinsky, Steven, Dalmau J, Beckmann, Jacques, Jacobson, L. P, O'Brien, S. J, Margolick, Joseph B, NIAID Center for HIV/AIDS Vaccine Immunology, Amalio Telenti* David B. Goldstein, Miro, J. M, Dongliang Ge, Margolick JB, Shianna, K. V, Cozzi-Lepri, Alessandro, Smith, J. P., Elizabeth T Cirulli, Amalio Telenti, Jacobson Lisa P., Carrington Mary, Goldstein, David B, Huldrych F. Günthard, Gumbs Curtis E., De, Luca A., Feng Sheng, Urban, TJ, Carrington, M, Antonarakis, Stylianos E, Kevin V Shianna, Ledergerber, B., Martinson Jeremy J., Martinson, Jeremy J., Goldstein, David B., Urban, T J, Urban Thomas J., Günthard, H. F, Margolick Joseph B., Cristina Mussini, Elizabeth T, Ge, Dongliang, Urban, Thomas J., Stylianos E. Antonarakis, Günthard, H.F., McMichael AJ, Wolinsky Steven M., Telenti Amalio, Martinez-Picado, J, Miro, J M, Cirulli ET, Huldrych F Günthard, Urban, Thomas J, Stephen J O'Brien, Martinez-Picado, Javier, Steven M. Wolinsky, Zhang K, Easterbrook P, Cirulli, Elisabeth T., Curtis E Gumbs, José M Miro, Shianna Kevin V., Jacobson, Lisa P, Wolinsky, S M, Lisa P. Jacobson, Günthard HF, Martinson, J.J., Norman L Letvin, Mallal Simon, Ledergerber, B, McMichael, A.J., McMichael, Andrew J, Smith, J.P., Gumbs, Curtis E., Günthard, Huldrych F., Smith, JP, Fellay, Jacques, Beckmann, Jacques S., Antonarakis, SE, Miro JM, Ledergerber, Bruno, Telenti A, Lisa P Jacobson, Wolinsky, Steven M., Roger Detels, Antonarakis, S E, Urban, T. J, Mallal, S., Günthard, Huldrych F, Obel, N, Cirulli, E T, Martinson JJ, Patrick Descombes, Ledergerber Bruno, Haynes Barton F., Mussini, C, Philippa Easterbrook, Descombes, P, Fellay J, Goldstein David B., Fellay, J, Margolick, Joseph B., Goldstein, D B, Steven M Wolinsky, Zhang Kunlin, Castagna A, Smith, Jason P, Descombes, Patrick, Gumbs, C E, Letvin Norman L., Goldstein, D.B., Margolick, JB, Smith JP, Smith, J. P, Beckmann, J. S, Wolinsky, S.M., Beckmann, Jacques S, Andrew J McMichael, Andrea De Luca, Beckmann, J.S., Jeremy J Martinson, Beckmann JS, NIAID Ctr HIV AIDS Vaccine Immunol, Shianna, KV, Haynes, Barton F., Gumbs, C.E., Jacques S. Beckmann, Ge D, McCarthy, M.I., Ge, D, McMichael Andrew J., Cirulli, ET, O'Brien, Stephen J., Norman L. Letvin, O\u27Brien, Stephen J., Dalmau Judith, Cozzi-Lepri, A., Haynes, B.F., Detels R, Ro Cozzi-lepri, Smith Jason P., Margolick, J.B., Günthard Huldrych F., Gumbs, Curtis, Zhang, KL, Colombo, S., Margolick, Joseph, De Luca A, Margolick, J. B, Beckmann Jacques S., O'Brien, Stephen, Shianna, Kevin V., Barton F Haynes, Dalmau, J, Kevin V. Shianna, Jacobson, LP, Wolinsky, SM, Martinez-Picado, J., Antonarakis, S. E, Mallal S, Carrington, Mary, Colombo Sara, Zhang, K., Letvin, N.L., Castagna, A, Obel, Niels, Mussini, Cristina, Detels Roger, O'Brien, S.J., Carrington, M., Obel Niels, Cirulli, E.T., Antonarakis, Stylianos E., Goldstein DB, Thomas J Urban, Descombes, P., Castagna, Antonella, Jose ́ M. Miro, Miro, JM, Sara Colombo, Judith Dalmau, O'Brien Stephen J., De Luca, A., Kunlin Zhang, Castagna Antonella, De Luca, A, Beckmann, JS, Stephen J. O’brien, Mussini Cristina, Easterbrook, P., Jacobson LP, Miro José M., Martinson, JJ, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI), Obel N, O'Brien, SJ, Shianna KV, Dalmau, Judith, McMichael, A J, Letvin, Norman Lee, Joseph B Margolick, Detels, R., Alessandro Cozzi-Lepri, CASTAGNA , ANTONELLA, Guenthard Huldrych F., Miró Meda, José M., Cozzi Lepri Alessandro, Martinez Picado Javier   +319 more
core   +2 more sources