Results 131 to 140 of about 475,380 (299)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Nature Genetics, 2016
C. Marshall, D. Howrigan, D. Howrigan, D. Merico, B. Thiruvahindrapuram, Wenting Wu, Douglas S. Greer, D. Antaki, A. Shetty, P. Holmans, P. Holmans, D. Pinto, Madhusudan Gujral, W. Brandler, D. Malhotra, D. Malhotra, Zhouzhi Wang, Karin V. Fuentes Fajarado, Michelle S. Maile, Stephan Ripke, Stephan Ripke, Ingrid Agartz, Ingrid Agartz, M. Albus, Madeline Alexander, F. Amin, J. Atkins, S. Bacanu, R. Belliveau, Sarah E. Bergen, Sarah E. Bergen, Marcelo Bertalan, Marcelo Bertalan, Elizabeth Bevilacqua, T. Bigdeli, Donald W. Black, Richard Bruggeman, N. Buccola, Randy L. Buckner, B. Bulik-Sullivan, B. Bulik-Sullivan, W. Byerley, W. Cahn, Guiqing Cai, Murray J. Cairns, Dominique Campion, Rita M Cantor, V. Carr, N. Carrera, S. Catts, Kimberley D. Chambert, Wei Cheng, C. R. Cloninger, David Cohen, P. Cormican, N. Craddock, N. Craddock, B. Crespo-Facorro, J. J. Crowley, David Curtis, David Curtis, Michal Davidson, K. Davis, F. Degenhardt, J. D. Favero, L. E. DeLisi, D. Dikeos, T. Dinan, S. Djurovic, S. Djurovic, G. Donohoe, G. Donohoe, E. Drapeau, J. Duan, J. Duan, F. Dudbridge, P. Eichhammer, Johan Eriksson, Johan Eriksson, Valentina Escott-Price, L. Essioux, A. Fanous, Kai-How Farh, M. Farrell, J. Frank, L. Franke, R. Freedman, Nelson B. Freimer, Joseph H. Friedman, A. Forstner, M. Fromer, G. Genovese, L. Georgieva, Elliot S. Gershon, I. Giegling, I. Giegling, P. Giusti-Rodríguez, S. Godard, J. Goldstein, J. Goldstein, Jacob Gratten, L. Haan, M. Hamshere, M. Hansen, T. Hansen, T. Hansen, V. Haroutunian, A. Hartmann, F. Henskens, S. Herms, S. Herms, J. Hirschhorn, J. Hirschhorn, J. Hirschhorn, P. Hoffmann, P. Hoffmann, A. Hofman, Hailiang Huang, Hailiang Huang, Masashi Ikeda, I. Joa, A. Kähler, René S. Kahn, L. Kalaydjieva, J. Karjalainen, David J. Kavanagh, Matthew C. Keller, Brian Kelly, James L. Kennedy, James L. Kennedy, Yunjung Kim, J. A. Knowles, B. Konte, Claudine Laurent, Phil H. Lee, Phil H. Lee, S. H. Lee, S. Legge, B. Lerer, Deborah L. Levy, Deborah L. Levy, Kung Yee Liang, Jeffrey A. Lieberman, Jouko Lönnqvist, C. Loughland, Patrik K. E. Magnusson, B. Maher, W. Maier, J. Mallet, M. Mattheisen, M. Mattingsdal, R. McCarley, Colm McDonald, Andrew M. McIntosh, S. Meier, C. Meijer, I. Melle, I. Melle, R. Mesholam-Gately, R. Mesholam-Gately, A. Metspalu, Patricia T. Michie, L. Milani, V. Milanova, Younes Mokrab, D. W. Morris, D. W. Morris, Bertram Müller-Myhsok, Bertram Müller-Myhsok, Kieran C. Murphy, Robin M. Murray, I. Myin‐Germeys, Igor Nenadić, D. Nertney, G. Nestadt, Kristin K. Nicodemus, L. Nisenbaum, Annelie Nordin, Eadbhard O’Callaghan, C. O’Dushlaine, Sang-Yun Oh, A. Olincy, L. Olsen, L. Olsen, F. A. O’Neill, J. V. Os, J. V. Os, C. Pantelis, G. Papadimitriou, E. Parkhomenko, M. Pato, T. Paunio, Diana O. Perkins, T. Pers, T. Pers, T. Pers, Olli Pietiläinen, Olli Pietiläinen, J. Pimm, A. Pocklington, J. Powell, Alkes L. Price, Alkes L. Price, A. Pulver, Shaun Purcell, D. Quested, H. B. Rasmussen, H. B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, A. Richards, A. Richards, J. Roffman, P. Roussos, D. Ruderfer, D. Ruderfer, V. Salomaa, A. Sanders, A. Sanders, A. Savitz, U. Schall, Thomas G Schulze, Thomas G Schulze, S. Schwab, E. Scolnick, Rodney J. Scott, L. Seidman, L. Seidman, Jianxin Shi, Jeremy M. Silverman, Jordan W. Smoller, Jordan W. Smoller, E. Söderman, C. Spencer, E. Stahl, E. Stahl, E. Strengman, J. Strohmaier, T. S. Stroup, J. Suvisaari, D. Svrakic, J. Szatkiewicz, S. Thirumalai, P. Tooney, Juha Veijola, P. M. Visscher, J. Waddington, D. Walsh, B. Webb, M. Weiser, D. Wildenauer, Nigel M. Williams, Stephanie Williams, S. Witt, A. Wolen, B. Wormley, Naomi R. Wray, J. Wu, Clement C. Zai, Clement C. Zai, R. Adolfsson, O. Andreassen, O. Andreassen, D. Blackwood, Elvira Bramon, J. Buxbaum, S. Cichon, D. Collier, D. Collier, A. Corvin, M. Daly, M. Daly, A. Darvasi, E. Domenici, E. Domenici, T. Esko, P. Gejman, P. Gejman, M. Gill, H. Gurling, C. Hultman, Nakao Iwata, A. Jablensky, Erik G Jönsson, Erik G Jönsson, Kenneth S. Kendler, G. Kirov, J. Knight, J. Knight, Doug Levinson, Qingqin Li, S. McCarroll, S. McCarroll, A. McQuillin, J. Moran, B. Mowry, M. Nöthen, Roel A. Ophoff, Roel A. Ophoff, Roel A. Ophoff, M. Owen, M. Owen, A. Palotie, A. Palotie, A. Palotie, C. Pato, T. Petryshen, D. Posthuma, D. Posthuma, D. Posthuma, Marcella Rietschel, B. Riley, Dan Rujescu, Dan Rujescu, P. Sklar, D. Clair, James T. R. Walters, T. Werge, T. Werge, T. Werge, Patrick F. Sullivan, Patrick F. Sullivan, M. O’Donovan, M. O’Donovan, Stephen W Scherer, B. Neale, J. Sebat   +326 more
semanticscholar   +1 more source