Results 171 to 180 of about 517,834 (299)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The interplay between genomic copy number variants, sleep, and cognition in the general population. [PDF]

Transl Psychiatry
Poulain C, Tesfaye R, Douard E, Martineau JL, Saci Z, Labbe A, Glahn DC, Almasy L, Elsabbagh M, Huguet G, Jacquemont S.   +10 more
europepmc   +2 more sources

Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes. [PDF]

Nature
Zou XZ, Hu F, Lou H, Burren OS, Li X, Megy K, Wheeler E, Wu Q, Atanur SS, Karpinski M, Loesch D, Fairhurst-Hunter Z, Deevi SVV, Oerton E, Wen S, Jiang X, Salvoro C, Mitchell J, Nag A, Hollis B, O'Neill A, AstraZeneca Genomics Initiative, Harrow J, MacArthur S, Wasilewski S, O'Dell S, Tian L, Smith KR, Del Angel G, Fabre M, Dhindsa RS, Wang Q, Petrovski S, Carss K.   +33 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes. [PDF]

Nature
Zou XZ, Hu F, Lou H, Burren OS, Li X, Megy K, Wheeler E, Wu Q, Atanur SS, Karpinski M, Loesch D, Fairhurst-Hunter Z, Deevi SVV, Oerton E, Wen S, Jiang X, Salvoro C, Mitchell J, Nag A, Hollis B, O'Neill A, AstraZeneca Genomics Initiative, Harrow J, MacArthur S, Wasilewski S, O'Dell S, Tian L, Smith KR, Del Angel G, Fabre M, Dhindsa RS, Wang Q, Petrovski S, Carss K.   +33 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Frameshift and Copy Number Variants in <i>SACS</i>-Related Neuropathy. [PDF]

Neurol Genet
Yuan JH, Higuchi Y, Ando M, Hiramatsu Y, Yoshimura A, Hobara T, Kojima F, Nakamura T, Sakiyama Y, Nozuma S, Ohyama S, Mitsui J, Tsuji S, Takashima H.   +13 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identification of copy number variants associated with BPES-like phenotypes [PDF]

core   +1 more source