Results 161 to 170 of about 1,695,985 (356)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Sensitive and Specific Real-Time Polymerase Chain Reaction Assays to Accurately Determine Copy Number Variations (CNVs) of Human Complement C4A, C4B, C4-Long, C4-Short, and RCCX Modules: Elucidation of C4 CNVs in 50 Consanguineous Subjects with Defined HLA Genotypes [PDF]

, 2007
Yee Ling Wu, Stephanie Savelli, Yan Yang, Bi Zhou, Brad H. Rovin, Daniel J. Birmingham, Haikady N. Nagaraja, Lee A. Hebert, C. Yung Yu   +8 more
openalex   +1 more source

Global variation in copy number in the human genome

Nature, 2006
R. Redon, S. Ishikawa, Karen R. Fitch, L. Feuk, L. Feuk, G. Perry, T. Andrews, H. Fiegler, M. Shapero, A. Carson, A. Carson, Wenwei Chen, Eun Kyung Cho, Stephanie Dallaire, J. Freeman, J. González, M. Gratacós, Jing Huang, Dimitrios Kalaitzopoulos, Daisuke Komura, J. MacDonald, C. Marshall, C. Marshall, R. Mei, Lyndal Montgomery, Keunihiro Nishimura, Kohji Okamura, Kohji Okamura, F. Shen, M. Somerville, J. Tchinda, A. Valsesia, Cara Woodwark, Fengtang Yang, Junjun Zhang, T. Zerjal, Jane Zhang, L. Armengol, D. Conrad, X. Estivill, X. Estivill, C. Tyler-Smith, N. Carter, H. Aburatani, Charles Lee, Charles Lee, K. W. Jones, S. Scherer, S. Scherer, M. Hurles   +49 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Numbers of Copy-Number Variations and False-Negative Rates Will Be Underestimated If We Do Not Account for the Dependence between Repeated Experiments [PDF]

, 2007
Andy G. Lynch, John C. Marioni, Simon Tavaré   +2 more
openalex   +1 more source

Origins and functional impact of copy number variation in the human genome

Nature, 2010
D. Conrad, D. Pinto, R. Redon, L. Feuk, O. Gokcumen, Yujun Zhang, J. Aerts, P. Campbell, Tomas W. Fitzgerald, C. Ihm, K. Kristiansson, J. MacDonald, Ifejinelo Onyiah, Andy Wing Chun, S. Robson, K. Stirrups, A. Valsesia, Klaudia Walter, John Wei, C. Tyler-Smith, N. Carter, Charles Lee, S. Scherer, M. Hurles   +23 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

The Fine-Scale and Complex Architecture of Human Copy-Number Variation [PDF]

, 2008
George H. Perry, Amir Ben‐Dor, Anya Tsalenko, Nick Sampas, Laia Rodríguez‐Revenga, Charles W. Tran, Alicia Scheffer, Israel Steinfeld, Peter Tsang, N. Alice Yamada, Han Soo Park, Jong‐Il Kim, Jeong Sun Seo, Zohar Yakhini, Stephen Laderman, Laurakay Bruhn, Charles Lee   +16 more
openalex   +1 more source

Functional impact of global rare copy number variation in autism spectrum disorders

Nature, 2010
D. Pinto, A. Pagnamenta, L. Klei, R. Anney, D. Merico, R. Regan, J. Conroy, T. Magalhães, C. Correia, B. Abrahams, J. Almeida, E. Bacchelli, Gary D Bader, A. Bailey, G. Baird, A. Battaglia, T. Berney, N. Bolshakova, S. Bölte, P. Bolton, T. Bourgeron, Sean Brennan, J. Brian, S. Bryson, A. Carson, G. Casallo, J. Casey, B. Chung, L. Cochrane, Christina M. Corsello, Emily L. Crawford, Andrew Crossett, C. Cytrynbaum, G. Dawson, M. Jonge, R. Delorme, Irene Drmic, E. Duketis, F. Duque, A. Estes, Penny Farrar, B. Fernandez, S. Folstein, E. Fombonne, C. Freitag, J. Gilbert, C. Gillberg, J. Glessner, J. Goldberg, A. Green, Jonathan Green, Stephen J. Guter, H. Hakonarson, E. Heron, M. Hill, R. Holt, J. Howe, G. Hughes, Vanessa Hus, R. Igliozzi, Cecilia Kim, S. Klauck, A. Kolevzon, Olena Korvatska, Vlad Kustanovich, C. Lajonchere, J. Lamb, Magdalena Laskawiec, M. Leboyer, A. Couteur, B. Leventhal, A. C. Lionel, Xiao-qing Liu, C. Lord, L. Lotspeich, Sabata C. Lund, E. Maestrini, W. Mahoney, Carine Mantoulan, C. Marshall, H. McConachie, C. McDougle, J. McGrath, W. McMahon, Alison K. Merikangas, O. Migita, N. Minshew, G. Mirza, J. Munson, S. Nelson, Carolyn Noakes, A. Noor, G. Nygren, G. Oliveira, K. Papanikolaou, J. Parr, B. Parrini, T. Paton, A. Pickles, M. Pilorge, J. Piven, C. Ponting, D. Posey, A. Poustka, F. Poustka, Aparna Prasad, J. Ragoussis, Katy Renshaw, Jessica Rickaby, W. Roberts, K. Roeder, B. Rogé, M. Rutter, L. Bierut, J. Rice, Jeff Salt, K. Sansom, Daisuke Sato, R. Segurado, A. Sequeira, Lili Senman, N. Shah, V. Sheffield, L. Soorya, I. Sousa, O. Stein, N. Sykes, Vera Stoppioni, Christina P Strawbridge, R. Tancredi, K. Tansey, Bhooma Thiruvahindrapduram, A. Thompson, Susanne A. Thomson, A. Tryfon, J. Tsiantis, H. Engeland, J. Vincent, F. Volkmar, S. Wallace, Kai Wang, Zhouzhi Wang, T. Wassink, C. Webber, R. Weksberg, Kirsty Wing, Kerstin Wittemeyer, Shawn Wood, Jing Wu, B. Yaspan, Danielle M Zurawiecki, L. Zwaigenbaum, J. Buxbaum, R. Cantor, E. Cook, H. Coon, M. Cuccaro, B. Devlin, S. Ennis, L. Gallagher, D. Geschwind, M. Gill, J. Haines, Joachim Hallmayer, Judith S Miller, A. Monaco, J. Nurnberger, A. Paterson, M. Pericak-Vance, G. Schellenberg, P. Szatmari, A. Vicente, V. Vieland, E. Wijsman, S. Scherer, J. Sutcliffe, C. Betancur   +176 more
semanticscholar   +1 more source