Results 191 to 200 of about 11,000,947 (301)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Copy number variation in bronchopulmonary dysplasia [PDF]

American Journal of Medical Genetics Part A, 2014
Thomas J, Hoffmann, Gary M, Shaw, David K, Stevenson, Hui, Wang, Cecele C, Quaintance, John, Oehlert, Laura L, Jelliffe-Pawlowski, Jeffrey B, Gould, John S, Witte, Hugh M, O'Brodovich   +9 more
openaire   +2 more sources

Droplet digital PCR assays for Pvmdr1 and Pvcrt-o gene copy number variation determination in Plasmodium vivax. [PDF]

Malar J
Srisutham S, Boonpeng K, Pitchayatanakorn P, Kijprasong K, Nosten FH, Day NPJ, Dondorp AM, Imwong M.   +7 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Establishing a prognostic threshold for total copy number variation within adult IDH-mutant grade II/III astrocytomas

Acta Neuropathologica Communications, 2019
Kanish Mirchia, Matija Snuderl, Kristyn Galbraith, Kimmo J. Hatanpaa, Jamie M. Walker, Timothy E. Richardson   +5 more
doaj   +1 more source

Influence of copy number variation of unknown significance on the pregnancy outcomes. [PDF]

Sci Rep
Wang Y, Wang Z, Chai Y, Wang J, Wang Y, Zhang P.   +5 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Somatic copy number variation as a prognostic marker for recurrence in never-smokers with early-stage lung adenocarcinoma. [PDF]

Int J Cancer
Vanstraelen S, Reiner A, Tan KS, Mastrogiacomo B, Dunne EG, Fick CN, Dycoco J, Abass A, Bott MJ, Sanchez-Vega F, Jones DR, Rocco G.   +11 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source