Results 41 to 50 of about 1,695,985 (356)

Adaptation by copy number variation increases insecticide resistance in the fall armyworm

Communications Biology, 2020
Understanding the genetic basis of insecticide resistance is a key topic in agricultural ecology. The adaptive evolution of multi-copy detoxification genes has been interpreted as a cause of insecticide resistance, yet the same pattern can also be ...
S. Gimenez, H. Abdelgaffar, G. L. Goff, F. Hilliou, C. Blanco, Sabine Hänniger, A. Bretaudeau, F. Legeai, N. Negre, J. Jurat-Fuentes, E. d’Alençon, Kiwoong Nam   +11 more
semanticscholar   +1 more source

Copy number variation genotyping using family information [PDF]

, 2013
BACKGROUND: In recent years there has been a growing interest in the role of copy number variations (CNV) in genetic diseases. Though there has been rapid development of technologies and statistical methods devoted to detection in CNVs from array data ...
Angela Rogers, Benjamin A Raby, Charles Lee, Iuliana Ionita-Laza, Jen-hwa Chu, Katayoon Darvishi, Ryan E Mills   +6 more
core   +2 more sources

A Copy Number Variation Morbidity Map of Developmental Delay

Nature Genetics, 2011
To understand the genetic heterogeneity underlying developmental delay, we compared copy number variants (CNVs) in 15,767 children with intellectual disability and various congenital defects (cases) to CNVs in 8,329 unaffected adult controls. We estimate
G. Cooper, Bradley P. Coe, S. Girirajan, J. Rosenfeld, Tiffany H. Vu, Carl A. Baker, C. Williams, H. Stalker, R. Hamid, V. Hannig, H. Abdel-Hamid, P. Bader, Elizabeth McCracken, D. Niyazov, K. Leppig, Heidi A. Thiese, M. Hummel, Nora Alexander, J. Gorski, J. Kussmann, V. Shashi, Krys Johnson, C. Rehder, B. Ballif, L. Shaffer, E. Eichler   +25 more
semanticscholar   +1 more source

Kernel-based aggregation of marker-level genetic association tests involving copy-number variation [PDF]

, 2013
Genetic association tests involving copy-number variants (CNVs) are complicated by the fact that CNVs span multiple markers at which measurements are taken. The power of an association test at a single marker is typically low, and it is desirable to pool
Breheny, Patrick, Li, Yinglei
core   +3 more sources

Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population

Molecular Genetics & Genomic Medicine, 2020
Background Primary ciliary dyskinesia (PCD) is a rare genetic disorder caused by functional impairment of cilia throughout the body. The involvement of copy number variation (CNV) in the development of PCD is largely unknown.
Kazuhiko Takeuchi, Yifei Xu, Masako Kitano, Kazuki Chiyonobu, Miki Abo, Koji Ikegami, Satoru Ogawa, Makoto Ikejiri, Mitsuko Kondo, Shimpei Gotoh, Mizuho Nagao, Takao Fujisawa, Kaname Nakatani   +12 more
doaj   +1 more source

Characterizing HDAC Pathway Copy Number Variation in Pan-Cancer

Pathology and Oncology Research, 2022
Background: Histone deacetylase (HDAC) plays a crucial role in regulating the expression and activity of a variety of genes associated with tumor progression and immunotherapeutic processes.
Shuming Yang, Shengzhi Xie, Xinying Shi, Dan Su, Bo He, Yang Xu, Zhefeng Liu   +6 more
doaj   +1 more source

Copy number variation signature to predict human ancestry [PDF]

, 2012
Background Copy number variations (CNVs) are genomic structural variants that are found in healthy populations and have been observed to be associated with disease susceptibility.
Asgharzadeh, Shahab, Pique-Regi, Roger, Pronold, Melissa, Vali, Marzieh   +3 more
core   +2 more sources

Copy number variation analysis based on AluScan sequences [PDF]

, 2014
BACKGROUND: AluScan combines inter-Alu PCR using multiple Alu-based primers with opposite orientations and next-generation sequencing to capture a huge number of Alu-proximal genomic sequences for investigation.
Chan, JC, Chen, JF, Chen, L, Ding, XF, Ke, XY, Ke, YB, Kwong, A, Leung, GKK, Ma, RC, Mat, WK, Poon, WS, Tan, TC, Wang, JM, Xu, L, Xu, MZ, Xu, XY, Yang, YF, Yu, CH   +17 more
core   +1 more source

Genome wide landscaping of copy number variations for horse inter-breed variability

Animal Biotechnology
Copy number variations (CNVs) have become widely acknowledged as a significant source of genomic variability and phenotypic variance. To understand the genetic variants in horses, CNVs from six Indian horse breeds, namely, Manipuri, Zanskari, Bhutia ...
Nitesh Kumar Sharma, Prashant Singh, Bibek Saha, Anuradha Bhardwaj, Mir Asif Iquebal, Yash Pal, Varij Nayan, Sarika Jaiswal, Shiv Kumar Giri, Ram Avatar Legha, T. K. Bhattacharya, Dinesh Kumar, Anil Rai   +12 more
doaj   +1 more source

Noise cancellation using total variation for copy number variation detection

BMC Bioinformatics, 2018
Background Due to recent advances in sequencing technologies, sequence-based analysis has been widely applied to detecting copy number variations (CNVs).
Fatima Zare, Abdelrahman Hosny, Sheida Nabavi   +2 more
doaj   +1 more source