Results 111 to 120 of about 2,816,421 (283)
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Strafrecht en sexualiteit [PDF]
, 1969 Onze geldende strafbepalingen aangaande sexuele gedragingen dateren in hoofdzaak uit de jaren 1870-1886, waarin het wetboek van strafrecht tot stand kwam.
Gutter, C. (Cor)
core
Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain
Advanced Science, EarlyView.A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio +3 more
wiley +1 more source
INFLUÊNCIA DAS CARACTERÍSTICAS TECNOLÓGICAS NA COR DA MADEIRA DE [PDF]
Ciência Florestal, 2004 Devido à importância da cor da madeira como componente de descrição da mesma, é que se realizou um estudo procurando verificar a influência dos componentes químicos na cor da madeira de diferentes clones de eucaliptos. Foram verificadas as quantidades de
Adalberto Caldas Oliveira +4 more
doaj
A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects
Advanced Science, EarlyView.Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi +12 more
wiley +1 more source
Aspecten van geweldpleging naar voorschriften van de Nederlandse staatsorganisatie [PDF]
, 1973 Tot de belangrijkste onderwerpen van het vak 'strafrecht', zoals dat aan de juridische faculteit van de Erasmus Universiteit Rotterdam – evenals trouwens aan die van de andere instellingen van wetenschappelijk onderwijs in Nederland, v.z.v.
Gutter, C. (Cor)
core
Advanced Science, EarlyView.Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang +11 more
wiley +1 more source
Development of a new hazelnut sandwich ELISA based on detection of Cor a 9, a major hazelnut allergen [PDF]
, 2010 The emerging health problem of food-induced allergic reactions, including life-threatening anaphylaxis, presents an important challenge to the food.
Cucu, Tatiana +3 more
core +1 more source
Advanced Science, EarlyView.This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu +8 more
wiley +1 more source