Results 71 to 80 of about 1,042,655 (286)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Optimal cross-validation in density estimation with the $L^2$-loss

, 2014
We analyze the performance of cross-validation (CV) in the density estimation framework with two purposes: (i) risk estimation and (ii) model selection.
Celisse, Alain
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Evaluating the Role of Hotel Departments in Sustainability Practices

Tourism and Hospitality
This study aims to assess the role of hotel departments in adapting to sustainable tourism indicators based on the resource conservation principle of Conservation of Resources (COR) Theory. Using the Best Worst Method (BWM) and Fuzzy TOPSIS, the findings
Seda Ozdemir Akgul, Ayse Cabi Bilge, Munevver Cicekdagi   +2 more
doaj   +1 more source

How and When Telework Improves Job Performance During COVID-19? Job Crafting as Mediator and Performance Goal Orientation as Moderator

Psychology Research and Behavior Management, 2021
Longjun Liu,1 Wenhai Wan,2 Qing Fan3 1School of Business, Nanjing University, Nanjing, People’s Republic of China; 2School of Business Administration, Huaqiao University, Quanzhou, People’s Republic of China; 3School of Management, Shanghai University ...
Liu L, Wan W, Fan Q
doaj  

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

When threats become catalysts: cognitive job crafting, work meaningfulness, and employee proactivity in high-insecurity contexts

Frontiers in Psychology
Drawing on Conservation of Resources (COR) theory, this study examined how cognitive job crafting stimulated employee innovation behavior and organizational citizenship behavior (OCB) through work meaningfulness, and how job insecurity moderated these ...
Lidan Liu, Yuhan Su, Zhongjun Wang
doaj   +1 more source

General properties of Nonsignaling Theories

, 2005
This article identifies a series of properties common to all theories that do not allow for superluminal signaling and predict the violation of Bell inequalities.
A. Acin, A. Peres, J. S. Bell, Ll. Masanes, N. Gisin, N. Gisin, N. J. Cerf, R. Renner   +7 more
core   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Modulating Oxygen Affinity to Enhance Liquid Products for the Electrochemical Reduction of Carbon Monoxide

SmartMat
Electrocatalytic CO reduction (COR) offers a promising alternative approach for synthesizing valuable chemicals, potentially at a lower carbon intensity as compared to conventional chemical production.
Jiayi Chen, Juan Manuel Arce‐Ramos, Ioannis Katsounaros, Emiel deSmit, Saifudin M. Abubakar, Yanwei Lum, Jia Zhang, Lei Wang   +7 more
doaj   +1 more source