Results 211 to 220 of about 1,598,812 (348)

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury. [PDF]

PLoS One
Liu D, Liu Y, Wu T, Hu J.
europepmc   +1 more source

MicroRNA‑138‑5p regulates the development of spinal cord injury by targeting SIRT1

, 2020
Jinchuan Chen, Rujie Qin
openalex   +2 more sources

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Optimization of cervical cord atrophy measurement using a real-world, multicentre dataset in multiple sclerosis. [PDF]

Front Neurol
Lukas C, Bellenberg B, Prados F, Valsasina P, Parmar K, Brouwer I, Pareto D, Rovira A, Sastre-Garriga J, Gandini Wheeler-Kingshott CAM, Amann M, Rocca MA, Filippi M, Yiannakas MC, Strijbis EMM, Barkhof F, Vrenken H.   +16 more
europepmc   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Identification and Successful Re‐Consent of Existing Cord Blood Donors for the Creation of Induced Pluripotent Stem Cell Lines

Stem Cells Translational Medicine, 2021
Keren Abberton, Tricia McDonald, Ngaire Elwood   +2 more
doaj   +1 more source

Acute Ventilatory Support During Whole-Body Hybrid Rowing in Patients With High-Level Spinal Cord Injury

, 2019
Isabelle Vivodtzev, Glen Picard, Felipe X. Cepeda, J. Andrew Taylor   +3 more
openalex   +2 more sources

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Does fear of childbirth in nulliparous women affect fetal outcomes? [PDF]

Rev Assoc Med Bras (1992)
Demir O, Ozbay G, Ozalp M, Sal H, Kayıkcı GO, Koç EA, Aran T, Osmanagaoglu MA.   +7 more
europepmc   +1 more source