Results 251 to 260 of about 1,598,812 (348)

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

Golden Hour perception in a public maternity hospital: challenges and potentialities under a multi-professional team's vision. [PDF]

Rev Paul Pediatr
Dias JR, Valete COS.
europepmc   +1 more source

Definition, Frequency and Risk Factors for Intra-Operative Spinal Cord Injury: A Knowledge Synthesis [PDF]

Michael G. Fehlings, Ayesha Quddusi, Andrea C. Skelly, Erika Brodt, Ali Moghaddamjou, Anahita Malvea, Nader Hejrati, Nisaharan Srikandarajah, Mohammed Ali Alvi, Shay Stabler-Morris, Joseph R. Dettori, Lindsay Tetreault, Nathan Evaniew, Brian K. Kwon   +13 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, EarlyView.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

Spinal Cord Leptomeningeal Enhancement as a Marker of Extensive Spinal Cord Involvement in Children With MOGAD. [PDF]

Neurol Neuroimmunol Neuroinflamm
Bartiromo S, Alves C, O'Mahony J, Yeh EA, Marrie RA, Narayanan S, Waters PJ, Gajofatto A, Bar-Or A, Banwell BL, Fadda G, Canadian Pediatric Demyelinating Disease Network.   +11 more
europepmc   +1 more source

Li/Al‐LDH Reinforced Polyacrylamide/Xanthan Gum Semi‐Interpenetrating Network Nano‐Conductive Hydrogels for Stress Sensing and Wearable Device Applications

Advanced Science, EarlyView.
PXL hydrogel is prepared by in situ polymerization of acrylamide (AM) between Li/Al‐LDH nanosheets and forming a semi‐interpenetrating network structure with xanthan gum (XG). The in situ polymerization of AM ensures the uniform distribution of Li/Al‐LDH within the hydrogel network.
Zhiwei Hu, Tuo Li, Yong Zheng, Shengxi Chen, Tong Wan, Hamdy Khamees Thabet, Zeinhom M. El‐Bahy, Dalal A. Alshammari, Hanhui Lei, Liqiang Chu, Yunlong Sun, Yaohui Guo, Yizhou Yang, Terence Xiaoteng Liu, Dapeng Cui, Zhanhu Guo, Huige Wei   +16 more
wiley   +1 more source

Combined Epidural Stimulation and Virtual Reality Rehabilitation for Comprehensive Neuromotor Recovery Following Spinal Cord Injury: A Single Arm Study. [PDF]

Global Spine J
Kaura S, Zafar S, Majumdar P.
europepmc   +1 more source

Programmable Hydrogels: Frontiers in Dynamic Closed‐Loop Systems, Biomimetic Synergy, and Clinical Translation

Advanced Science, EarlyView.
This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang, Bohan Yin, Behzad Shiroud Heidari, George Youssef, Monika Gosecka, Mateusz Gosecki, Fernando G. Torres, Siu Hong Dexter Wong, Jagan Mohan Dodda   +8 more
wiley   +1 more source

MiR499-5P loaded MSC derived exosomes affect oxidative stress and inflammatory response after spinal cord injury by targeting genes. [PDF]

J Orthop Surg Res
Pang L, Qi L, Wang H, Zhu T, Wang Y.
europepmc   +1 more source