Results 261 to 270 of about 1,598,812 (348)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Athlete-derived extracellular vesicles protect against spinal cord injury via inhibition of neuronal ferroptosis. [PDF]

Sci Adv
Wang J, Ge X, Lang C, Xu W, Hu T, Wang L, Hu F, Sun Y, Zhang F, Cai W, Liu W, Zhang W, Rong Y.   +12 more
europepmc   +1 more source

The basic helix–loop–helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord

, 2005
Alida Filippi, Natascia Tiso, Gianluca Deflorian, Elisabetta Zecchin, Marino Bortolussi, Francesco Argenton   +5 more
openalex   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Correction: Effect of body mass index on survival after spinal cord injury. [PDF]

Front Neurol
Fallah N, Noonan VK, Thorogood NP, Kwon BK, Kopp MA, Schwab JM.   +5 more
europepmc   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Cord care practices and related outcomes among caregivers in two referral facilities in Ghana: a cross-sectional study. [PDF]

BMC Pediatr
Amponsah-Kodua G, Agyei-Baffour P, Okyere P, Acheampong PR, Karikari JK, Akohene Mensah K, Tagoe N, Naab JTM, Owusu-Dabo E.   +8 more
europepmc   +1 more source

SpaBalance: Balanced Learning for Efficient Spatial Multi‐Omics Decoding

Advanced Science, EarlyView.
SpaBalance is a computational framework that harmonizes multi‐omics learning via gradient equilibrium and dual‐stream feature decomposition, achieving superior clustering accuracy, biological interpretability, and scalable integration of three or more spatial omics modalities.
Yingbo Cui, Yong Zhao, Canqun Yang, Tao Tang, Xiangke Liao, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuansong Zeng   +8 more
wiley   +1 more source

Impact of SARS-CoV-2 Infection and Vaccination on Pregnancy Outcome and Passive Neonatal Immunity. [PDF]

Cells
Uehre GM, Grabar V, Grage-Griebenow E, Klemens O, Scholz L, Hoymann N, Alboradi S, Ignatov A, Tchaikovski S, Busse M.   +9 more
europepmc   +1 more source

4D Printing of Magnetically Responsive Shape Memory Polymers: Toward Sustainable Solutions in Soft Robotics, Wearables, and Biomedical Devices

Advanced Science, EarlyView.
Merging 4D printing with magneto‐responsive shape memory polymers opens new avenues for intelligent, reconfigurable systems. This review navigates cutting‐edge fabrication techniques, magnetic fillers, and smart polymer matrices, unveiling their potential in soft robotics, biomedical devices, and wearable tech.
Kiandokht Mirasadi, Mohammad Amin Yousefi, Liuchao Jin, Davood Rahmatabadi, Majid Baniassadi, Wei‐Hsin Liao, Mahdi Bodaghi, Mostafa Baghani   +7 more
wiley   +1 more source