Results 31 to 40 of about 1,593,330 (305)

CRISPR Genome Editing: How to Make a Fantastic Method Even Better

open access: yesCells, 2021
CRISPR genome editing describes targeted mutagenesis involving a programmable DNA scissor consisting of a protein (Cas9) bound to a short RNA [...]
Cord Brakebusch
doaj   +1 more source

Calibrated forceps model of spinal cord compression injury. [PDF]

open access: yes, 2015
Compression injuries of the murine spinal cord are valuable animal models for the study of spinal cord injury (SCI) and spinal regenerative therapy.
Ariza, Jeanelle   +3 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

open access: yesFrontiers in Physiology, 2012
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated ...
Alexander G. Rabchevsky   +12 more
doaj   +1 more source

Disorder and interference: localization phenomena [PDF]

open access: yes, 2016
The specific problem we address in these lectures is the problem of transport and localization in disordered systems, when interference is present, as characteristic for waves, with a focus on realizations with ultracold atoms.Comment: Notes of a lecture
Delande, Dominique, Müller, Cord A.
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord

open access: yesBiomedicines
Background/Objectives: Traumatic brain injury (TBI) occurs after a sudden mechanical force to the skull and represents a significant public health problem.
Tamara Janković   +7 more
doaj   +1 more source

Posthumanist Cultural Studies: Taking the Nonhuman Seriously

open access: yesOpen Cultural Studies, 2022
In recent years, there has been a pronounced (re-)turn to questions of ontology, matter, and realism in the humanities and social sciences. What all these theoretical formations have in common is their profound challenge to human exceptionalism.
Cord Florian
doaj   +1 more source

(Re-)Assembling Cultural Studies

open access: yesCulture Unbound: Journal of Current Cultural Research, 2022
This paper proceeds from the assumption that the Anthropocene is characterized by a profound impurity and ‘messiness’. It argues that in order to be able to better tackle the immense complexity of the contemporary world, Cultural Studies needs to be ...
Florian Cord
doaj   +1 more source

A Multi‐Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The optimal treatment for neurosarcoidosis myelitis is uncertain. We characterize incident neurosarcoidosis myelitis and assess treatment response by MRI and clinical scales. Methods Incident probable or definite neurosarcoidosis myelitis in adults was retrospectively identified from 13 academic medical centers.
Giovanna S. Manzano   +39 more
wiley   +1 more source

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