Results 121 to 130 of about 293,348 (199)

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman, Yohannes Shiferaw, David Conesa   +2 more
wiley   +1 more source

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

The Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu, Andrew E. Worthy, Alan J. Emanuel   +2 more
wiley   +1 more source

CO2 chemoreflex contributions to ventilatory long‐term facilitation

The Journal of Physiology, EarlyView.
Abstract figure legend To determine whether changes in CO2 chemoreflex sensitivity contribute to ventilatory long‐term facilitation (LTF), we tested the hypothesis that hypercapnic acute intermittent hypoxia (AIH) induces ventilatory LTF and enhances peripheral, but not central, chemoreceptor CO2 chemoreflex sensitivity.
Susan V. Cross, Elizabeth Keen, Tom E. Nightingale, Zubair Ahmed, George M. Balanos, Joseph F. Welch   +5 more
wiley   +1 more source

Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA

Glia, Volume 74, Issue 11, November 2026.
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden, David John Calkins   +1 more
wiley   +1 more source

Impaired Motor Function in a Zebrafish Stathmin‐2 Knockout Model

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Stathmin‐2 (STMN2) is a microtubule‐associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.
Tyler J. N. Gurberg, Ziyaan A. Harji, Christian J. Rampal, Joséphine Sacy‐Richer, Amy Wang, Esteban C. Rodríguez, Gary A. B. Armstrong   +6 more
wiley   +1 more source

Postpartum anemia and maternal wellbeing: A cohort analysis of the WOMAN‐2 trial

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 117-126, October 2026.
Abstract Objective We examined the association between postpartum anemia and maternal wellbeing in women who gave birth with anemia. Methods We conducted a cohort analysis using secondary data from the WOMAN‐2 trial. Between August 2019 and September 2023, women with moderate or severe anemia who were giving birth vaginally were recruited from ...
The WOMAN‐2 Trial Collaborators, Judith Lieber, Katharine Ker, Folasade Adenike Bello, Rizwana Chaudhri, Kiran Javaid, Aasia Kayani, Mwansa Ketty Lubeya, Projestine Muganyizi, Oladapo Olayemi, Bellington Vwalika, Monica Arribas, Eni Balogun, Amy Brenner, Amber Geer, Poppy Mallinson, Raoul Mansukhani, Danielle Prowse, Haleema Shakur‐Still, Ian Roberts, France Donnay, Racheal Phiri, Tina Lavender, Ghazala Mahmud, Haleema Shakur‐Still, Ian Roberts, Jens Kieckbusch, James Lawrence, Sari Watson, Jane Armitage, Maria Quigley, Olufemi T. Oladapo, Sabaratnam Arulkumaran, Imelda Bates, Rizwana Chaudhri, Bukola Fawole, Katharine Ker, Ian Roberts, Haleema Shakur‐Still, Eni Balogun, Danielle Prowse, Danielle Beaumont, Charlotte Fleming, Monica Arribas, Collette Barrow, Llion Roberts, Amber Geer, Julio Gil Onandia, Madeleine Cargill, Andrew Thayne, Christiana Alao, Petula Buck, Raoul Mansukhani, Tim Collier, Katharine Ker, Mbwana Mohammed, Amy Brenner, Myriam Benyahia, Judith Lieber, Haleema Shakur‐Still, Ian Roberts, Rizwana Chaudhri, Aasia Kayani, Kiran Javaid, Projestine Muganyizi, Alice Kawala, Rose Temba, Oladapo Olayemi, Folasade Adenike Bello, Olujide Okunade, Bellington Vwalika, Aziz‐un‐Nisa Abbasi, Ruqqia Sultana, Shehla Noor, Ansa Islam, Sadia Bibi, Sundus Khan, Wajeeha Khurshid, Shahida Magsi, Basma Zia, Haleema Yasmin, Khadija Bano, Saba Khan, Naheed Fatima, Bushra Sher Zaman, Sohail Mahmood Chaudhry, Shakila Yasmin, Khiaynat Sarwar Hashmi, Nadia Babar, Arif Tajammul, Alia Bashir, Farah Siddique, Fouzia Perveen, Nusrat Shah Kamal, Riffat Jaleel, Sarah Kazi, Aruna Hira, Pushpa Makhija, Syeda Batool Mazhar, Nasira Tasnim, Saera Afghan, Mussarat Batool, Sobia Luqman, Fouzia Kashif, Shaista Hifaz Abro, Javeria Abro, Najma Ghaffar, Rakhshanda Mushtaq, Safia Bibi, Shamsa Humayun, Zohra Khanum, Noreen Akmal, Shamila Ijaz Munir, Aisha Malik, Amna Zia Eusaph, Sofia Manzoor, Khola Yousaf, Misbah Kausar, Yasmeen Waqas, Naila Ehsan, Aisha Siddiqa, Uzma Suhail Afridi, Nosheen Sikandar, Rehana Kamaal, Mehnaz Khakwani, Rashida Perveen, Huma Quddusi, Hajira Masood, Syeda Ali, Asma Akhter, Mubashra Samina, Sana Ishfaque, Rizwana Chaudhri, Humaira Bilqis, Shahid Irshad Rao, Saima Ashraf, Uzma Shaheen, Tayyiba Wasim, Natasha Rasool, Nabeela Waheed, Khansa Iqbal, Shahida Husain Tarar, Rizwana Khalid, Rubina Sohail, Shehla Kanwal, Shagufta Saeed Sial, Humera Noreen, Naila Israr, Shehla Baqai, Asifa Siraj, Luzango Maembe, Julius Nyambarino, Enid Simon Chiwanga, Lazaro Y. Madeha, Francis Ngimwichi Joseph, Evelyne Ludovick, Baya H. Kissiwa, Sangalala Mtingele, Vincent Tarimo, Alfred Secha, Hudson August Manyanga, Idrisa Hussein, Alphonce Moyo, Delila Msigwa, France John Rwegoshora, Delfina Mkenda, Mojisola Mobolaji‐Ojibara, Michael Babalola, Owa Olorunfemi Oludele, Samuel Ojo, Oladipo Aremu, Kehinde Ogundairo, Oyewole Tunde Aremu, Gazaal Rasheedat, Iman Usman, Auwal Shuaibu, Adewale Adeyemi, Olufemi Aworinde, Theresa Irinyenikan, Mwansa Ketty Lubeya, Kenneth Chanda   +180 more
wiley   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Advantages of delayed clamping of the umbilical cord in comparison with timely clamping

, 2017
The aim of this abstract is to compare the advantages and disadvantages of delayed clamping of the umbilical cord compared with the early one.Analyzing the results obtained, it can be concluded that the delayed clamping of the cord has more advantages ...
Onwujekwe, Udodi
core   +1 more source

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Aged mice exhibited impaired motor behavior and neuromuscular hypoexcitability, yet cortical output to muscle was enhanced, and motor cortex layer V pyramidal neurons were hyperexcitable, with altered synaptic inputs and excitability‐related transcriptional changes.
Jose A. Viteri, Nathan R. Kerr, Fereshteh B. Darvishi, Anna Roshani Dashtmian, Charles D. Brennan, Sindhuja N. Ayyagari, Peter J. Moore, Meifang Wang, Harper Snyder, Baocong Yu, Joseph M. Santin, W. David Arnold   +11 more
wiley   +1 more source

Uterus‐preserving surgery for placenta accreta spectrum: An expert, illustrated review of techniques and its outcomes

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1932-1949, October 2026.
Uterus‐preserving strategies for PAS include myometrial resection and leaving placenta in situ, differing in surgical principles, complications, and follow‐up. Myometrial resection offers definitive treatment with lower rates of delayed morbidity, while leaving the placenta in situ minimizes surgical risk but is associated with prolonged follow‐up ...
Pedro Viana Pinto, Albaro José Nieto‐Calvache, Rafael José Vieira, Abdalla Mousa, Hooman Soleymani majd, Rozi Aditya Aryananda, José Miguel Palacios‐Jaraquemada   +6 more
wiley   +1 more source