Results 41 to 50 of about 9,787 (201)

Circulating prostaglandin E2 concentrations decrease at birth in premature lambs

Frontiers in Pediatrics
RationaleDuring pregnancy, prostaglandin E2 (PGE2) is released from the placenta and circulates in relatively high concentrations in the fetus. As PGE2 suppresses breathing, PGE2 concentrations must decrease after birth, but the timing and mechanisms ...
Timothy J. R. Panneflek, Janneke Dekker, Kelly J. Crossley, Kelly J. Crossley, Cailin Diedericks, Cailin Diedericks, Kristel L. A. M. Kuypers, Ebony R. Cannata, Ebony R. Cannata, Paige J. Riddington, Paige J. Riddington, Femmie E. Bloem, Alison M. Thiel, Alison M. Thiel, Thomas van den Akker, Thomas van den Akker, Graeme R. Polglase, Graeme R. Polglase, Arjan B. te Pas, Stuart B. Hooper, Stuart B. Hooper, Indya M. Davies, Indya M. Davies   +22 more
doaj   +1 more source

Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial

Maternal Health, Neonatology and Perinatology, 2019
Background Experiments have shown improved cardiovascular stability in lambs if umbilical cord clamping is postponed until positive pressure ventilation is started. Studies on intact cord resuscitation on human term infants are sparse.
Ola Andersson, Nisha Rana, Uwe Ewald, Mats Målqvist, Gunilla Stripple, Omkar Basnet, Kalpana Subedi, Ashish KC   +7 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

To clamp or not to clamp late?

Journal of Pediatric and Neonatal Individualized Medicine, 2013
When resuscitating a neonate, one encounters controversial issues and a great deal of confusion. These issues include the question as to when should the umbilical cord be clamped.
Nicoletta Iacovidou, Aggeliki Syggelou, Theodoros Xanthos   +2 more
doaj   +1 more source

The Effect of Delayed Cord Clamping (DCC) on Haemoglobin Levels and Oxygen Saturation Levels in Newborns

Babali Nursing Research, 2023
Background: The case of iron deficiency anaemia in infants is a serious health problem because it interferes with mental and cognitive development. DCC prolongs blood flow from the placenta to the baby through the umbilical cord, increases blood volume,
Siti Naili Ilmiynai, Eka Mustika Yanti, Baiq Disnalia Siswari   +2 more
doaj   +1 more source

WITHDRAWN: Early cord clamping is the experimental intervention not delayed cord clamping

American Journal of Obstetrics and Gynecology, 2018
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
openaire   +2 more sources

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

The hematological status between early and delayed cord clamping after normal delivery in term infants at Damnoen Saduak Hospital

Thai Journal of Obstetrics and Gynaecology, 2013
Objective:To compare the hematological status between early and delayed cord clamping and determine adverse outcomes 48 hours after birth.Material and method: 148 singletons uncomplicated term pregnancies were selected according to inclusion criteria of
Nuanpun Tanmoun
doaj  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source