The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton +6 more
wiley +1 more source
Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis. [PDF]
Sanz-Cabanillas JL +8 more
europepmc +1 more source
Behaviour Support in Dentistry Core Outcomes (BeSiDe‐CO): A Core Outcome Set Development Study
ABSTRACT Objectives To develop a Core Outcome Set suitable for adults and children for use in studies of Dental Behaviour Support (DBS) techniques, including non‐pharmacological DBS, sedation and General Anaesthesia research. Methods Two systematic reviews generated a preliminary list of candidate outcomes that were shared with Key Stakeholders (KSG ...
Caoimhin Mac Giolla Phadraig +22 more
wiley +1 more source
Severe Dengue and Dengue-Malaria Coinfection: A Case Series from a Referral Hospital in Montería, Colombia. [PDF]
Avilés-Vergara PA +6 more
europepmc +1 more source
ABSTRACT Rural Chinese adolescents face significant mental health challenges shaped by cumulative risks across ecological systems, particularly individual, family and peer domains. However, the underlying mechanism linking cumulative risk to mental health problems remains insufficiently explored.
Chen Deng +3 more
wiley +1 more source
Territorial Socioeconomic Vulnerability and Clinical Outcomes in Pediatric Cancer at a Colombian Referral Center. [PDF]
Galeano-Páez C +7 more
europepmc +1 more source
Dear Influencers: Don't Disturb Amphibians and Reptiles for More Followers
Animal Conservation, EarlyView.
José Guerrero‐Casado, Ricardo Reques
wiley +1 more source
Key practices for ethical research during scientific expeditions
In many cases, expeditionary practices undermined local knowledge and expertise. This perspective advocates for a shift from parachute science towards a collaborative research approach. We reflect on and suggest best practices during scientific expeditions within research teams and in the team's interactions with different communities.
Nelsy Niño‐Rodríguez +12 more
wiley +1 more source
Cost-effectiveness of the timing of respiratory extracorporeal membrane oxygenation initiation in pediatric patients. [PDF]
Camelo-Pardo G +7 more
europepmc +1 more source
High-Intensity Functional Concurrent Training for Physical Fitness, Body Composition, and Psychological Outcomes in Schoolchildren: Protocol for a Randomized Controlled Trial. [PDF]
Durán-López N +6 more
europepmc +1 more source

