Results 101 to 110 of about 284,987 (280)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Spatial Period-Doubling Agglomeration of a Core-Periphery Model with a System of Cities [PDF]
The orientation and progress of spatial agglomeration for Krugman's core--periphery model are investigated in this paper. Possible agglomeration patterns for a system of cities spread uniformly on a circle are set forth theoretically.
Akamatsu, Takashi +2 more
core +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
A CORE-PERIPHERY MODEL WITH A KNOWLEDGE TRANSFER MECHANISM
Doboku Gakkai Ronbunshuu D, 2008 我国における若年労働人口の減少を補うために，労働者間の知識・技術の伝達とその高度化の必要性が指摘されている．労働者間の学習効果と，それにより達成される知識・技術の伝達は，労働者の空間的配分パターンに大きく依存する．本稿では，労働者間の学習メカニズムを考慮した都市経済システムモデル（Core-Periphery model ）を構築し，若年労働人口の減少が都市システムの人口配分パターンに与える影響を理論的に解析した．その結果，若年労働人口の減少によって，都市システム全体の人口集積が進むこと，及び，それによってシステム全体の学習効果が高まり，知識・技術水準の高度化が期待できることが明らかになった．さらに，ある都市において若年労働者のみを誘致する政策は ...
Shintaro SATO, Takashi AKAMATSU
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Long-run identifying restrictions on VARs within the AS-AD framework [PDF]
Bayoumi and Eichengreen’s (BE, 1994) article has been very influent in the empirics of the core-periphery view of fixed exchange rate agreements. They rely on the basic AS-AD macroeconomic model in order to identify supply and demand shocks through long ...
Pentecôte, J.-S.
core +1 more source
Core periphery model, test 64DT-211. Final report [PDF]
, 1970 The cyclic corrosion resistance capability of an R-1 type periphery featuring a multiple layer Z-liner thermalized rerolled pyrofoil wrapper was experimentally measured. This test employed an SX-5 graphite core and simulated fuel elements.
openaire +2 more sources
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Trade Liberalisation and Agglomeration with Firm Heterogeneity - Forward and Backward Linkages [PDF]
This paper studies the impact of trade costs reduction on geographical concentration in the presence of firm heterogeneity and overhead type of export fixed costs.
Toshihiro Okubo
core
Spatial Period-Doubling Agglomeration of a Core-Periphery Model with a System of Cities [PDF]
, 2009 The orientation and progress of spatial agglomeration for Krugman's core--periphery model are investigated in this paper. Possible agglomeration patterns for a system of cities spread uniformly on a circle are set forth theoretically.
Akamatsu, Takashi +2 more
core