Results 131 to 140 of about 69,694 (301)

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Community Medicine Competencies for Postgraduate Year Residents: A Qualitative Study Based on the Six ACGME Competencies in Taiwan

Journal of General and Family Medicine
Background Community medicine is a key topic of training for postgraduate year (PGY) doctors. When physicians practice in community settings, the traditional six core competencies defined by the Accreditation Council for Graduate Medical Education (ACGME)
Shih‐Ming Li, Jin‐Shang Wu, Hsin‐Yun Chang, Pei‐Ling Sung, Zhi‐Cheng Fang, Zih‐Jie Sun   +5 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Bridging the gap: the mediating role of self-efficacy in the impact of workload on core competencies among pediatric nurses

BMC Nursing
Background Pediatric nurses operate in high-stakes environments characterized by emotional, cognitive, and physical demands. Excessive workload can undermine nurses’ ability to perform effectively, particularly when compounded by low self-efficacy.
Abdelaziz Hendy, Rasha Kadri Ibrahim, Naglaa Hassan Abuelzahab, Amna Nagaty Aboelmagd, Hanan F. Alharbi, Nasiru Mohammed Abdullahi, Lisa Babkair, Yasir S. Alsalamah, Zainab Attia Abdallah, Waad Hasan Ali, Wesam Taher Almagharbeh   +10 more
doaj   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Curriculum Evaluation Using the IFNA Generalist Competencies for Family Nursing Practice

, 2016
Using a blueprint based on program evaluation theory, the program was assessed based on the key concepts identified in the IFNA Position Statement on Generalist Competencies for Family Nursing Practice.
Gray, Bobbe, Curry, Donna M., Eustace, Rosemary W., Anderson, Kathy   +3 more
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Evaluating relationships between organisational core competencies and individuals' competencies. [PDF]

Determining core competence has been increasingly considered as a vital strategic approach towards a sustainable competitive advantage by researchers and decisionmakers.
Essmail, Essmail Ali.
core  

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

CO-OPERATING TO COMPETE IN HIGH VELOCITY GLOBAL MARKETS: THE STRATEGIC ROLE OF FLEXIBLE SUPPLY CHAIN ARCHITECTURES

Continued value creation is paramount for the survival of firms competing in today's high velocity global business environment. This paper presents a conceptual framework for understanding how firms can create and capture value within a highly volatile ...
Gow, Hamish R., Oliver, Lance D., Gow, Neil G.   +2 more
core