Results 61 to 70 of about 1,049,724 (311)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Earth, Planets and Space, 2023 The Earth’s magnetic field originated in the fluid core, the so-called core field, is the dominant contribution to the geomagnetic field. Since ancient times, the core geomagnetic field has been used primarily for geographical orientation and navigation ...
Marina Puente-Borque +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Magnetic Field Alignment with Dense Cores in the Transition between Cloud and Core Scales
The Astrophysical JournalIn a magnetically dominated model of star formation, we expect to see alignments between the magnetic field orientation of star-forming dense cores and the cloud-scale magnetic field. A. Pandhi et al.
Sean Yin +9 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An Inductive Approach to Documenting the "Core" and Evolution of the IS Field
Communications of the Association for Information Systems, 2007 This article inductively examines the question of the IS field’s core. We argue that as a socially constructed field, the core aspects of IS can be identified from the work conducted and published by members of the IS community. The abstracts (including titles) of 1,197 IS studies in three premier IS journals for the past 26 years were examined to ...
Jaejoo Lim, Guang Rong, Varun Grover
openaire +2 more sources
Core-CT connection a newsletter From the Core-CT Project . 2002: Oct.
, 2002 Began with Sept. 2001; ceased with Oct. 2003.; Numbering begins with No. 2 (Oct.
core
Zhongguo dianli, 2020 The noise of the transformer is mainly generated by the vibration of the oil tank, which is mainly generated by the vibration of the iron core, while the vibration of the iron core is mainly generated by the electromagnetic force.
Chao FAN +7 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source