Results 111 to 120 of about 3,991,740 (295)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Impact of Core Stability Training on Neuromuscular Performance Among Young Soccer Players: A Randomized Interventional Trial

Applied Sciences
(1) Soccer is the world’s most popular sport, with over 265 million players worldwide. The core muscles play a crucial role in supporting the body’s upper and lower limbs, and training to strengthen these muscles has been shown to improve athletic ...
Roni Gottlieb, Rafat Ibrahim, Asaf Shalom, Julio Calleja Gonzalez   +3 more
doaj   +1 more source

Investigation of exit-velocity stratification effects on jets in a crossflow (STRJET) [PDF]

, 1974
Program determines flow field about jets with velocity stratification exhausting into crossflow. Jets with three different types of exit-velocity stratification have been considered: (a) jets with relatively high-velocity core, (b) jets with relatively ...
Ziegler, H.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Refueling of field-reversed configuration core via axial plasmoids injection

Nuclear Fusion
This study successfully developed a refueling technique for a field-reversed configuration (FRC) via axial plasmoid injection and demonstrated it on the FAT-CM device at Nihon University.
T. Asai, T. Takahashi, D. Kobayashi, T. Seki, Y. Takeuchi, O. Mitarai, J. Morelli, N. Mizuguchi, S. Dettrick, H. Gota, T. Roche, T. Matsumoto, M. Binderbauer, T. Tajima, M. Inomoto, T. Takahashi   +15 more
doaj   +1 more source

Timing of the martian dynamo: New constraints for a core field 4.5 and 3.7 Ga ago. [PDF]

Sci Adv, 2020
Mittelholz A, Johnson CL, Feinberg JM, Langlais B, Phillips RJ.   +4 more
europepmc   +1 more source

Magnetic Fields of the Starless Core L 1512

The Astrophysical Journal
Abstract We present JCMT POL-2 850 μm dust polarization observations and Mimir H-band stellar polarization observations toward the starless core L 1512. We detect the highly ordered core-scale magnetic field traced by the POL-2 data, of which the field orientation is consistent with the parsec-scale magnetic fields traced by Planck data,
Sheng-Jun Lin, Shih-Ping Lai, Kate Pattle, David Berry, Dan P. Clemens, Laurent Pagani, Derek Ward-Thompson, Travis J. Thieme, Tao-Chung Ching   +8 more
openaire   +6 more sources